Thalamic Innervation of the Monkey Striatum

猴纹状体的丘脑神经支配

• 批准号: 6999143
• 负责人: DINESH V RAJU
• 金额: $ 3.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999143
• 关键词: Parkinson' s disease; Saimiri; afferent nerve; basal ganglia; brain mapping; cerebral cortex; confocal scanning microscopy; corpus striatum; dopamine receptor; glutamate transporter; immunocytochemistry; immunoelectron microscopy; motor cortex; neuroanatomy; neuropathology; neurophysiology; predoctoral investigator; stereotaxic techniques; synapses; thalamic nuclei

DESCRIPTION (provided by applicant): The thalamus is a complicated structure that relays and processes motor-related information from the basal ganglia to the cerebral cortex. It also sends highly topographic and massive projections back to the striatum, the primary input nucleus of the basal ganglia. However, the circuitry of the thalamostriatal system, and its role in regulating basal ganglia function during normal movement and during disease states, such as Parkinson's Disease, is poorly understood. The objective of this research proposal is to characterize the microcircuitry of the thalamostriatal projection, which arises from the ventral anterior (VA) and ventral lateral (VL) motor thalamic nuclei using tract tracing, confocal microscopy, and immunocytochemical electron microscopy techniques. The first aim will determine the synaptology of VA/VL thalamostriatal afferents, and the second aim will investigate the differential innervation of VA/VL afferents with the direct and indirect pathways of the basal ganglia. Knowledge gained from these experiments will advance our understanding of interactions between the thalamus and the basal ganglia and provide valuable information on the mechanisms by with this interaction may contribute to the normal and pathological function of the basal ganglia.

描述（由申请人提供）： 丘脑是一种复杂的结构，可将与运动相关的信息从基底神经节传递到大脑皮层。它还将高度地形和大规模投影发送回纹状体，纹状体是基底神经节的主要输入核。然而，丘脑纹状体系统的回路及其在调节正常运动期间和疾病状态期间（例如帕金森氏病）中的作用，众所周知。该研究建议的目的是使用腹侧前（VA）和腹侧（VL）运动丘脑丘脑核的丘脑纹状体投射的微电路，并使用牵引痕迹，共焦显微镜和免疫电子显微镜技术。第一个目的将确定VA/VL丘脑纹状体传入的突触，第二个目标将研究VA/VL传入的差异神经与基底神经节的直接和间接途径的差异神经。从这些实验中获得的知识将提高我们对丘脑与基底神经节之间相互作用的理解，并通过这种相互作用提供有关该机制的有价值的信息，这可能有助于基底神经节的正常和病理功能。