Genetics and Molecular Biology Parkinsonism

遗传学和分子生物学帕金森病

基本信息

批准号：
8337451
负责人：
DENNIS WILLIAM DICKSON
金额：
$ 62万
依托单位：
MAYO CLINIC JACKSONVILLE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-15 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8337451
关键词：
Achievement Administrator Advisory Committees Aging Alzheimer&apos s Disease American Animal Model Animals Area Autopsy Award Biochemical Biological Assay Biological Markers Biological Models Book Chapters Boston Brain Case Study Cell Culture Techniques Cell Line Cell model Cells China Chromosomes, Human, Pair 17 Clinic Clinical Clinical Data Cognition Disorders Collaborations Collection Common Data Element Communities Complement Complication Consensus County Custom Cytopathology DNA Data Data Element Data Set Databases Dementia Development Diagnostic Disease Disease Association Doctor of Philosophy Drug Delivery Systems Drug Formulations Dystonia Education and Outreach Educational Activities Enrollment Eukaryotic Initiation Factor-4G Europe Evaluation Exclusion Criteria FTD with parkinsonism Faculty Family Fellowship Foundations Foxes Frontotemporal Dementia Funding Genes Genetic Genetic Materials Genetic Screening Genetic screening method Goals Grant Histologic Human Hypercapnic respiratory failure Impaired cognition Incidental Discoveries Institutes Interdisciplinary Study International Internet Israel Japan Knowledge LRRK2 gene Laboratories Lead Leadership Lewy Bodies Lewy Body Disease Link Longitudinal Studies MPTP Poisoning Medical Education Medical Research Mental Depression Mentors Methods Minnesota Mission Modeling Molecular Molecular Biology Molecular Genetics Motor Movement Disorders Multiple System Atrophy Mutation National Institute of Neurological Disorders and Stroke Neurodegenerative Disorders Neurologic Neurologist Northern Africa Onset of illness Operon Outcome Paper Parkinson Disease Parkinson&apos s Dementia Parkinsonian Disorders Pathogenesis Pathologic Patient Education Patient Recruitments Patients Peer Review Pennsylvania Pharmacologic Substance Phosphotransferases Play Postdoctoral Fellow Preclinical Drug Evaluation Predisposition Process Productivity Progressive Supranuclear Palsy Prospective Studies Protein Binding Domain Proteomics Publications RNA Interference Recruitment Activity Reporting Research Research Personnel Research Project Grants Research Proposals Resource Sharing Resources Restless Legs Syndrome Risk Risk Factors SNCA gene Saimiri Sampling Scandinavia Scheme Scientist Series South America Staging Subgroup Sum Support Groups Syndrome System Taiwan Targeted Research Tetanus Helper Peptide Therapeutic Therapeutic Uses Time Toxic effect Training Translating Translational Research Travel Universities Variant Veins Washington Woman Work advanced disease alpha synuclein arm base brain tissue candidate identification clinical material corticobasal degeneration cytotoxicity disability dynactin early onset follow-up gene discovery genetic linkage genetic risk factor genetic variant genome wide association study genome-wide illness length inclusion criteria inhibitor/antagonist insight interest kindred leucine-rich repeat kinase 2 meetings member molecular pathology neuroblastoma cell neuropathology next generation novel outreach population based posters pre-clinical pre-doctoral prevent programs prospective skills small molecule small molecule libraries success therapeutic target viral gene delivery web page

项目摘要

The Udall Center for Excellence in Parkinson Disease Research at the Mayo Clinic is an integrated, multidisciplinary research program of neurologists, neuropsychologists, geneticists, neuropathologists and basic scientists in the study of the "Genetics and Molecular Biology of Parkinsonism." The Center draws upon the clinical strengths of the Mayo Clinic Movement Disorder Section and longitudinal studies of Parkinson disease (PD) and dementia with Lewy bodies (DLB) for the clinical material used in the research projects, as well as strong institutional commitment to PD research. The research proposed is highly synergistic despite the wide range of expertise and scientific background of the members of the Udall team. Each member of the team brings unique knowledge and skill sets to the mission, and together we are greater than the sum of the parts. The work proposed builds upon highly successful and productive cores that have been working together for over a decade. The clinical, genetic and pathologic resources are rivaled by few centers. The Mayo Udall Center is a unique complement to the Udall Center program. Success of our Udall Center has been based upon building successful collaborations and generous sharing of resources and data. This proposal has the overarching goal to better understand Lewy-related PD, which is the most common form of PD. Lewy bodies are also the hallmark of DLB and PD with dementia (PDD). How PDD and DLB relate to each other is unknown, but this non-motor complication of PD is of increasing interest to the Parkinson community. Strengths of our Udall Center are the large collection of multi-incident PD families, a proven track record of success in discovery of PD genes and a large collection of PD, PDD and DLB brains in a well annotated brain bank. The research proposal has three projects and five cores: Project 1. "Identification of genetic risk factors that predict disease onset, susceptibility and progression of PD," (PL: Matthew J. Farrer, PhD); Project 2. "Identification of candidate therapeutics for a-synuclein aggregation and cytotoxicity," (PL: Shu-Hui C. Yen, PhD); Project 3. "Molecular pathology of Lewy-related cognitive dysfunction," (PL: Dennis W. Dickson, MD); Core A. Administrative (CL: Dennis W. Dickson, MD); Core B. Clinical (CL: Zbigniew K. Wszolek, MD); Core C. Genetic (CL: Matthew J. Farrer PhD); Core D. Neuropathology (CL: Dennis W. Dickson MD) and Core E. Education and Outreach (CL: Ryan J. Uitti, MD).

梅奥诊所的帕金森氏病研究中心的UDALL卓越研究中心是一项综合的，多学科的研究计划，是神经病学家，神经心理学家，遗传学家，神经病理学家和基础科学家的一项综合学科研究计划。该中心借鉴了梅奥临床运动障碍部分的临床优势，以及帕金森病（PD）和痴呆症的纵向研究，其中包括Lewy Bodies（DLB），用于研究项目中使用的临床材料，以及对PD研究的强有力的机构承诺。尽管Udall团队成员的专业知识和科学背景广泛，但提出的研究还是高度协同的。团队的每个成员都为任务带来了独特的知识和技能，我们共同比零件的总和还要多。拟议的作品建立在已经共同努力十多年的非常成功和生产的核心上。临床，遗传和病理资源与几个中心相媲美。 Mayo Udall中心是Udall Center计划的独特补充。我们的Udall中心的成功一直基于建立成功的合作和慷慨的资源和数据共享。该提案的总体目标是更好地了解与Lewy相关的PD，这是PD的最常见形式。路易尸体也是DLB和PD的标志，具有痴呆症（PDD）。 PDD和DLB之间的相互关系是未知的，但是PD的这种非运动并发症引起了帕金森社区的兴趣。我们的Udall中心的优势是大量的多物种PD系列，在发现PD基因的发现成功方面有着可靠的记录，以及大量注释的脑库中的PD，PDD和DLB大脑的大量收集。该研究提案有三个项目和五个核心：项目1。“鉴定预测疾病发作，易感性和PD进展的遗传风险因素”，（PL：MATTHEW J. FARRER，PHD）；项目2。“鉴定A核蛋白聚集和细胞毒性的候选疗法”（PL：Shu-Hui C. Yen，PhD）；项目3。“与Lewy相关的认知功能障碍的分子病理学”（PL：Dennis W. Dickson，MD）；核心A.行政管理（CL：Dennis W. Dickson，马里兰州）；核心B.临床（CL：Zbigniew K. Wszolek，MD）;核心C.遗传（CL：Matthew J. Farrer博士）； Core D.神经病理学（CL：Dennis W. Dickson MD）和Core E. E. E.教育与外展（CL：Ryan J. Uitti，医学博士）。