LONGITUDINAL CLINICAL OUTCOME COMPARISONS WITH 5 INDEXES

5项指标的纵向临床结果比较

• 批准号: 6790943
• 负责人: Robert M Kaplan
• 金额: $ 23.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790943
• 关键词: aging; behavioral /social science research tag; cataract surgery; congestive heart failure; data collection methodology /evaluation; health surveys; hip prosthesis; human subject; longitudinal human study; outcomes research; patient oriented research; psychometrics; quality of life; questionnaires

The overall objective of Project 2 is to prospectively compare generic versus disease-targeted measures of Health-Related Quality of Life (HRQOL) in three patient populations. We will study six generic instruments: the EuroQol (EQ-5D). Health Utilities Index Mark 2 (HUI2), the Self-Administered Quality of Well-being scale (QWB-SA), the Health and Activities Limitation Index (HALex), the Medical Outcomes Study 36 Item Short Form (SF-36), and the Standard Gample. In addition 3 utility based scores will be imputed from SF-36 data. Each measure we will be administered to 300 patients in each of three categories: Arthritis - hip replacement, vision impairment - cataract extraction with lens replacement and comprehensive management of congestive heart failure. A disease-targeted measure will also be given to each clinical group. Subjects will be recruited from three academic medical centers: the University of California, San Diego, University of California, Los Angeles and the University of Wisconsin. Each subject will be measured at baseline and again at 1, 3, and 6 months. The specific aims of the study are: 1) To evaluate discdminant validity of the nine generic indexes in three patient populations. 2) To evaluate the responsiveness of the measures to clinical change. 3) To evaluate the validity and responsiveness of genedc versus disease-targeted measures. 4) To develop guidelines for the use of HRQOL measures in the three patient populations. 5) To evaluate three methods for imputing utility based scores from SF-36 data. In addition to traditional psychometric analysis, responsiveness and reproducibility will be estimated. Multivariate longitudinal modeling will also be conducted. The results of the study should provide guidance on the selection of measures for outcomes studies and cost/utility analysis.

项目2的总体目标是在三个患者群体中前瞻性地比较健康相关生活质量(HRQOL)的通用测量和疾病定向测量。我们将研究六种通用工具： EuroQol(EQ-5D)。健康效用指数标记2(HUI2)、自我管理幸福感质量量表(QWB-SA)、健康和活动限制指数(HALex)、医疗结果研究36项简表(SF-36)和标准配对。此外，3个基于实用工具的分数将从SF-36数据中计算出来。 我们将对三个类别中的每个类别的300名患者实施我们的每项措施：关节炎-髋关节 人工晶状体置换，视力障碍--白内障摘除人工晶状体置换术 充血性心力衰竭的治疗。还将向每个临床组提供针对疾病的措施。受试者将从三个学术医学中心招募：加州大学圣地亚哥分校、加州大学洛杉矶分校和威斯康星大学。每个受试者都将在基线时进行测量，并在1、3和6个月时再次测量。这项研究的具体目的是： 1)评价9项通用指标在3个患者群体中的预测效度。 2)评价措施对临床变化的反应能力。 3)评估GENEDC与疾病针对性措施的有效性和响应性。 4)制定在三个患者群体中使用HRQOL测量的指南。 5)评价三种从SF-36数据中输入基于效用的分数的方法。 除了传统的心理测量学分析外，还将评估响应性和重复性。 还将进行多变量纵向建模。研究结果应为选择成果研究和成本/效用分析的措施提供指导。