Characterizing Communicating Genetic Risk Alzheimer's

表征传播遗传风险阿尔茨海默病

• 批准号: 7211279
• 负责人: Robert C. Green
• 金额: $ 17.56万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7211279
• 关键词: African American; Alzheimer' s disease; anxiety; apolipoprotein E; behavioral /social science research tag; biotechnology; cardiovascular disorder risk; caucasian American; clinical research; depression; family genetics; gene interaction; genetic counseling; genetic screening; genetic susceptibility; health services research tag; high throughput technology; human genetic material tag; human subject; patient oriented research; racial /ethnic difference; single nucleotide polymorphism

DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator Award in patient-oriented research. The candidate is a professor of neurology and epidemiology at the Boston University with an established record as a researcher, clinician, and educator. The proposed mentoring and research plans are focused on two major themes: (1) discovering and quantifying ways of characterizing genetic risk for Alzheimer's disease and (2) creating and evaluating real-world procedures for communicating genetic risk. The Mentoring Plan takes advantage of the candidate's experiences and position as director of a large and diverse program in patient-oriented research with Alzheimer's disease patients and their families. Under the supervision of the K24 awardee, each trainee will develop and carry out independent research projects from design to publication. Trainees will obtain hands-on experience in multiple aspects of patient-oriented research including focus group and survey development, small and large scale clinical trials, and epidemiological studies. Trainees will participate in research seminars, methodology and grant-writing workshops, meetings on multidisciplinary consensus conferences and in the ongoing K30 Clinical Research Curriculum at BU. Funding for statistical consultation will assure that biostatistical support is readily available. Formal coursework at the BU School of Public Health will be encouraged. In all activities, trainees will follow a detailed mentoring plan with a schedule of structured activities, and with clear roles, specific responsibilities and concrete evaluation plans measuring knowledge, skill and productivity. The Research Plan builds upon two large funded R01 projects, the Multi-Institutional Research in Alzheimer's Genetic Epidemiology (MIRAGE) Study and the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study. Each of these studies has been competitively renewed at least once, and has extensive ongoing operations and data available for trainee education and analysis of data. This award will also help refine the candidate's own research skills in the area of genetic epidemiology and lay the groundwork for expanding the MIRAGE Study and the REVEAL Study in new directions.

描述（由申请人提供）：这是K24中级护理研究者奖的申请，以患者为导向的研究。候选人是波士顿大学神经病学和流行病学教授，并拥有研究员，临床医生和教育工作者的既定记录。拟议的指导和研究计划的重点是两个主要主题：（1）发现和量化表征阿尔茨海默氏病的遗传风险的方法，以及（2）创建和评估现实世界中传达遗传风险的程序。指导计划利用了候选人的经验和职位，是与阿尔茨海默氏病患者及其家人的大型多样化计划的主任。在K24获奖者的监督下，每个学员将在设计到出版物中开发和开展独立的研究项目。学员将在以患者为导向的研究的多个方面获得动手经验，包括焦点小组和调查开发，小规模和大型临床试验以及流行病学研究。学员将参加研究研讨会，方法论和赠款写作研讨会，关于多学科共识会议的会议以及BU正在进行的K30临床研究课程。统计咨询的资金将确保可容易获得生物统计支持。将鼓励BU公共卫生学院的正式课程。在所有活动中，学员将遵循一个详细的指导计划，并具有结构化活动的时间表，并具有明确的角色，特定的职责和具体评估计划，以衡量知识，技能和生产力。该研究计划基于两个大型资助的R01项目，即阿尔茨海默氏症遗传流行病学（Mirage）研究的多机构研究以及阿尔茨海默氏病的风险评估和教育（揭示）研究。这些研究中的每一项至少进行了一次竞争性更新，并且具有广泛的正在进行的操作和数据可用于学员的教育和数据分析。该奖项还将有助于完善候选人在遗传流行病学领域的研究技能，并为扩大海市rage研究和揭示研究的基础奠定了基础。