Non-Classical Manifestations of Primary Hyperparathyroidism

原发性甲状旁腺功能亢进症的非典型表现

• 批准号: 7206236
• 负责人: SHONNI J SILVERBERG
• 金额: $ 15.34万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7206236
• 关键词: blood chemistry; bone density; calcification; calcium disorder; cardiovascular disorder; cardiovascular function; clinical research; clinical trials; comorbidity; human subject; hyperparathyroidism; neuropsychology; parathyroidectomy; patient oriented research; photon absorptiometry; postoperative state; sign /symptom; statistics /biometry; ultrasonography; vascular resistance

DESCRIPTION (provided by applicant): The central goal of this application is to further my development as a clinical investigator, while enhancing my opportunities to mentor fellows and promising young faculty interested in careers in clinical research. Patient-oriented clinical research has been the cornerstone of my medical career. My main research focus has been the investigation of primary hyperparathyroidism (PHPT). I have studied the clinical presentation of the disease; its natural history with and without surgery; medical treatment options; and malignant PHPT (parathyroid cancer). I plan to continue and expand my collaborative research program in PHPT. My hypothesis is that sufficiently sensitive techniques will detect sub-clinical features of PHPT that have up to now eluded detection, and that these features may regress with surgical cure. Having shown this to be true in the skeleton, the research in this proposal will investigate possible cardiovascular and neuropsychological abnormalities. The research will also characterize a non-classical presentation of PHPT with normal serum calcium levels; and will investigate the increase in bone density that follows parathyroidectomy. These projects should enhance our understanding of modern PHPT. In addition, given data supporting non-intervention in many patients with PHPT (NIH Surgical Guidelines, 2002), these studies could have major public health implications, leading to a new standard-of-care for the evaluation and management of PHPT. The projects will provide fertile training ground for mentoring young investigators in patient oriented research in the field of metabolic bone disease. I have had significant success as a mentor, with 11 current or past trainees, 2 with Endocrine Fellows Foundations grants, and one currently holding a K23/K30 Award. As Co-Director of our NIH Postdoctoral Fellowship Program, I have regular access to Endocrine Fellows, as well as residents, students and junior faculty interested in participating in my research. The environment at Columbia is outstanding, with a large and supportive Endocrine Division, and an NIH funded Clinical Research Center. However, without further support for my research and mentoring effors, I will have to increase my clinical and administrative responsibilities. The K24 mechanism will allow me to achieve my goals: continued productivity in the clinical investigation of parathyroid disease, with protected time for mentoring fellows and junior colleagues interested in patient oriented clinical research as a career path.

描述（由申请人提供）： 该应用程序的核心目标是进一步发展作为临床研究者的发展，同时增强了我指导研究员的机会，并有望有望对临床研究中的职业感兴趣的年轻教师。以患者为导向的临床研究一直是我医疗生涯的基石。我的主要研究重点是对原发性甲状旁腺功能亢进症（PHPT）的研究。我研究了该疾病的临床表现。它的自然历史有或没有手术；医疗选择；和恶性PHPT（甲状旁腺癌）。我计划继续在PHPT中扩大我的协作研究计划。我的假设是，足够敏感的技术将检测到现在已经避开检测的PHPT的次临床特征，并且这些特征可能会通过手术治疗进行回归。在骨骼中证明这是正确的，该提案中的研究将研究可能的心血管和神经心理学异常。该研究还将表征具有正常血清钙水平的PHPT的非经典表现。并将研究甲状旁腺切除术后的骨密度增加。这些项目应该增强我们对现代PHPT的理解。此外，鉴于支持许多PHPT患者不干预的数据（NIH手术指南，2002年），这些研究可能具有重大的公共卫生影响，从而为PHPT评估和管理提供了新的护理标准。这些项目将为指导年轻的研究人员在代谢骨病领域的患者研究中提供肥沃的培训地。作为导师，我取得了巨大的成功，有11名现任或过去的学员，2名获得了内分泌研究员基金会的赠款，还有一名目前持有K23/K30奖。作为我们NIH博士后奖学金计划的联合主任，我定期获得内分泌研究员以及有兴趣参加我的研究的居民，学生和初级教师。哥伦比亚的环境非常出色，具有大型和支持性的内分泌部门，以及NIH资助的临床研究中心。但是，在没有进一步支持我的研究和指导效率的情况下，我将不得不增加我的临床和行政责任。 K24机制将使我实现自己的目标：在甲状旁腺疾病的临床研究中持续的生产力，并保护了指导研究员的保护时间和对患者临床研究感兴趣的初级同事作为职业道路。