Autism in Young Children:Restricted/Repetitive Behaviors

幼儿自闭症：限制/重复行为

• 批准号: 6806226
• 负责人: MICHAEL L CUCCARO
• 金额: $ 24.74万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6806226
• 关键词: autism; behavior test; behavioral /social science research tag; biomarker; child behavior; child psychology; clinical research; communication behavior; conduct disorder; disease /disorder classification; human subject; longitudinal human study; mental health epidemiology; pediatrics; phenotype; preschool child (1-5); psychometrics; social behavior; video recording system

Restricted and repetitive behaviors and interests (RRBs) are a defining characteristic of autism. While essential to clinical diagnosis, this group of behaviors is woefully understudied relative to social and communication problems in autism. Specifically, there is limited understanding of the development, course, and uniqueness of RRBs. The objective of this project is to examine RRBs in young children (ages 2 and 3 years of age) with autism or autism spectrum disorder (ASD). RRBs comprise a diverse set of behaviors such as repetitive motor actions, rituals, routines, and compulsions. The presence and quality of RRBs have been shown to adversely affect both adaptive and social functioning and also predict severity of autism symptoms. Characterizing the developmental course of RRBs will allow for examination of their direct impact on social and communication outcomes in autism. This is directly relevant to individualizing treatment as well as constructing subgroups based on clusters of symptoms. Prior investigations of RRBs in autism have studied older individuals or those with severe cognitive impairments, but not young children with autism and a range of cognitive functioning. However, it is clear from studies of young children with developmental disabilities such as Down syndrome that RRBs emerge much earlier and should be investigated in this 2- to 3-year old age period. This study will elucidate the developmental aspects of RRBs in autism versus typical development and developmental disabilities. This comparative, longitudinal study will document the early development of RRBs and how these behaviors differ in three groups of young children: 1) children with autism/ASD between 2 and 3 years of age; 2) children with developmental disabilities (DD) between 2 and 3 years of age, and 3) typically developing children (TD). Both DD and TD groups will be matched to the autism/ASD groups on the basis of mental age. All children will be serially evaluated with a comprehensive battery of measures to assess the occurrence, frequency, and intensity of RRBs as well as social, communicative, and behavioral functioning. This is the first study to examine RRBs in young children with autism or ASD using multiple methods (direct observation and informant report). The current study will (1) document the course and developmental trajectory of RRBs in young children with autism vs. non-autism; (2) examine the relationship of RRBs to social-communicative outcomes in autism; (3) construct groupings of RRBs that may constitute significant subtypes in autism based on co-occurrence, patterns over time, and intensity and (4) use RRBs as the basis for phenotypic stratification in this data set to identify genes associated with RRBs and/or autism.

限制和重复的行为和兴趣（RRBs）是自闭症的一个决定性特征。虽然这组行为对临床诊断至关重要，但相对于自闭症的社会和沟通问题，这组行为的研究却很少。具体来说，人们对RRBs的发展、过程和独特性的理解有限。该项目的目的是检查患有自闭症或自闭症谱系障碍（ASD）的幼儿（2岁和3岁）的RRBs。RRBs包括一系列不同的行为，如重复性运动动作、仪式、惯例和强迫行为。RRBs的存在和质量已被证明对适应和社会功能产生不利影响，并预测自闭症症状的严重程度。