Translational Hematology and Oncology Research Laboratory Expansion Project

描述(由申请人提供)：在过去的十年里，克利夫兰临床陶西格癌症研究所(TCI)在癌症护理、临床试验和癌症转化研究方面取得了巨大的增长。这一扩张最初是由于2000年搬进了一座新建筑，其中4楼是癌症研究所研究实验室的所在地。最初，实验室是在血液和肿瘤学分子治疗中心内管理的，但在获得研究资金、使用实验室组件的新临床试验和招募转化型癌症研究人员方面的成功导致了新的转化性血液和肿瘤学研究(TOR)系的成立，由Jaroslaw Maciejeski博士领导，他是这项提案的PI。目前，实体设施包括私人投资机构的实验室、共用设备区、会议室、工作人员和行政办公室以及供血液学/肿瘤学和博士后研究员使用的空间。目前，45名科技人员和10名辅助研究人员占用了可用空间，其能力已经耗尽。在2000年建造新建筑之前，癌症研究所的研究人员占据了医院邻近M楼的实验室，现在通过一座桥与新建筑相连。这个空间建于1928年，上一次翻修是在1950年代，由于有新的空间可用，现已废弃，但如果进行翻修并达到目前的研究实验室标准，它将大大扩大科学家的有效实验室和办公桌空间，并允许进一步招聘。 由于分配给新调查人员的实验室空间短缺，TCI和TOR的进一步增长受到了阻碍，其中包括计划中的招聘。在靠近现有实验室和共享仪器核心的地方开设一个新的潮湿实验室空间，对于这个蓬勃发展的部门的持续增长和扩张至关重要，并将符合NIH ARRA倡议的精神。我们建议在这里进行一次3600平方米的大翻修。英国《金融时报》实验室空间可容纳最多4个新的PI和一个共享的仪器核心，这将有效地额外腾出500平方英尺。英国《金融时报》主要板凳空间的现有空间。扩大雷神的研究能力对于TCI的使命至关重要，其中包括提供最先进的癌症护理、旨在提高癌症诊断和治愈率的转化研究、临床研究和对下一代内科科学家的教育。我们申请的具体目标是翻新和改造目前无法使用的实验室空间，为转化型癌症研究计划的扩展提供场所。翻修将改善进入该设施的机会，翻新并适应目前的实验室标准和相关的物理设施，并导致安装固定的研究设备。

DESCRIPTION (provided by applicant): In the last decade the Cleveland Clinic Taussig Cancer Institute (TCI) has demonstrated tremendous growth in terms of cancer care, clinical trials and translational cancer research. This expansion was initially enabled by a move into a new building in 2000, of which the 4th floor houses the Cancer Institute research laboratories. Originally, laboratories were administered within the Center for Hematology and Oncology Molecular Therapeutics, but the success in obtaining research funding, new clinical trials with laboratory components and recruitment of translational cancer researchers has led to the formation of the new Department of Translational Hematology and Oncology Research (THOR) headed by Dr. Jaroslaw Maciejewski, the PI of this proposal. Currently, the physical facilities include the laboratories of the PIs, shared equipment areas, a conference room, offices for staff and administration as well as room for hematology/oncology and postdoctoral fellows. Currently, 45 scientists and technicians and 10 support research personnel occupy the available space, the capacity of which has been exhausted. Prior to construction of the new building in 2000, cancer institute researchers occupied laboratories in the adjacent M building of the hospital, now connected via a bridge with the new building. This space, erected in 1928 and last renovated in the 1950s, has been abandoned due to the availability of new space, but if renovated and brought up to current research laboratory standards, it would allow for significant expansion of the effective laboratory and desk space for scientists and allow for further recruitment. Further growth of the TCI and THOR, which includes planned recruitment, has been impeded by a shortage of laboratory space to be assigned to new investigators. Opening a new wet laboratory space in close proximity to the existing laboratories and shared instrumentation core is essential for continuing growth and expansion of this thriving department and would be in the spirit of NIH ARRA initiative. We propose here a major renovation of 3600 sq. ft. of laboratory space to house up to 4 new PIs and a shared instrumentation core, which would effectively free an additional 500 sq. ft. of the existing space for primary bench space. Expansion of THOR research capabilities is essential for the mission of the TCI, which includes provision of the most advanced cancer care, translational research aiming at improving diagnosis and cure rates of cancer, clinical research and education of the next generation of physician scientists. The specific aim of our application is to renovate and adapt currently unusable laboratory space to provide a venue for expansion of the translational cancer research program. The renovation will improve access to the facility, renovate and adapt to current laboratory standards and associated physical facilities and lead to installation of fixed research equipment.