Cardiovascular and Regenerative Sciences in WIMR Phase II

描述（由申请人提供）：该项目，威斯康辛医学研究所二期心血管和再生科学，是威斯康辛医学研究所战略倡议的一个组成部分。WIMR包含了三个阶段的努力，将威斯康星大学医学和公共卫生学院（SMPH）的研究事业广泛地整合为一个物理和智力资源，确保基础和临床科学完全整合到发现和转化的引擎中，从而促进创新和应用于广泛的疾病驱动计划。目前的C06提案是WIMR二期项目的一个子集，二期项目耗资1.34亿美元，占地26.6万平方英尺（GSF），由七层实验室组成，建在WIMR一期已经完成的基础设施之上。WIMR二期的主要科学重点领域是神经科学、心血管科学、再生医学、分子医学和视觉科学研究的整合。以及基础癌症生物学和再生医学在外科专业的应用。该提案要求部分支持WIMR II的一个研究楼层的建设和装修，重点是心血管和心脏再生科学。在这个提案中，我们将全面建设和装备WIMR II的一层楼，提供超过25,000平方英尺（ASF）的高度集成空间。正如所示和讨论的那样，共享基础设施确保了规模经济，并进一步增强了协作。这些资源是专门针对心血管和心脏再生科学定位。综上所述，我们建议扩建和装备WIMR二期的一层楼，配备25,000个ASF，耗资近1900万美元，本次请求为1500万美元。这将在一个高度跨学科的设施中为至少12至15个研究小组提供最先进的设施。

DESCRIPTION (provided by applicant): This project, Cardiovascular and Regenerative Sciences in WIMR Phase II, is an integral component of the Wisconsin Institutes for Medical Research (WIMR) strategic initiative. WIMR embodies a three phase effort to broadly incorporate the research enterprise of the University of Wisconsin School of Medicine and Public Health (SMPH) into a physical and intellectual resource that ensures complete integration of basic and clinical sciences into an engine of discovery and translation, thereby facilitating innovation and application to a broad swath of disease-driven initiatives. The present C06 proposal is a subset of the WIMR Phase II project, a $134M, 266,000 gross square foot (GSF) facility comprised of seven laboratory floors constructed on top of underpinnings already completed during WIMR Phase I. The major scientific focus areas of WIMR II are the integration of neuroscience, cardiovascular science, regenerative medicine, molecular medicine, and visual science research, as well as fundamental cancer biology and regenerative medicine applications in surgical specialties. This proposal requests partial support to construct and fit-out one research floor in WIMR II focused upon cardiovascular and cardioregenerative sciences. In this proposal, we will fully build-out and equip one floor of WIMR II, providing more than 25,000 assignable square feet (ASF) of highly integrated space. As shown and discussed, shared infrastructure ensures economy of scale and further enhances collaboration. These resources are specific to the cardiovascular and cardioregenerative science positioned there. In conclusion, we propose to build-out and equip one floor of WIMR Phase II, with 25,000 ASF, at a cost of nearly $19M, with this request being $15M. This will provide state-of-the-art facilities in a highly transdisciplinary facility for at least 12 to 15 research teams.