Renovation and Infrastructure Upgrade of Laboratory Research Wing at Johns Hopkin

描述（由申请人提供）：本提案旨在对约翰霍普金斯彭博公共卫生学院（JHSPH）主楼北翼的实验室设施进行基础设施升级和现代化改造。JHSPH成立于1916年，是同类学校中历史最悠久，规模最大的学校。学校的遗产已经并将继续成为将基础研究转化为改善美国和世界公众健康的战略之一。八层楼的北翼建于1962年，拥有四分之一的学校实验室致力于生物医学研究。北翼的科学奋进将围绕人类疾病的遗传，环境和宿主易感性风险因素进行主题组织。研究课题将包括流感和其他传染病、空气和水携带的环境危害、疟疾和其他病媒传播疾病、生殖障碍以及人类基因组如何对其环境作出反应的基础研究。机械、电气和管道基础设施的使用年限接近50年，已经超过了其使用寿命。主要目标包括：1。更换和升级设施中过时和老化的公用设施基础设施，以提供安全可靠的生物医学实验室环境; 2.更新和现代化老化或过时的实验室，以满足当前和未来的需求，同时促进研究人员之间的合作，使用开放和灵活的实验室设计和布局; 3.通过与同行和更资深的研究人员的实验室的空间接触，为有前途的年轻研究人员提供孵化器环境;以及，4。建设学校的第一个LEED认证的实验室设施。北翼的基础设施老化和实验室可用性的相关下降一直是学校在过去五年的头号资本项目的优先事项，但资金限制无限期地推迟了它。由于在咨询服务和施工文件编制方面的前期投资，JHSPH能够在分配的时间框架内迅速开展并完成该项目，并在此过程中保持和创造专业和施工相关的工作。部分费用分摊也包括在内，以表明机构承诺。增强的基础设施升级将提高公用事业系统的容量，可靠性和冗余要求，而翻新将改善与从事前沿科学的现代实验室研究设施相关的布局，饰面和设备需求。这个项目是关键，使现有的JHSPH调查人员保持竞争力的资金和学校的能力，以招募新的高素质的科学人才。该项目将有助于确保JHSPH继续开拓发现，促进公众的健康，无论是现在还是将来。

DESCRIPTION (provided by applicant): This proposal is for an infrastructure upgrade and modernization of the laboratory facilities housed in the North Wing of the principal building of the Johns Hopkins Bloomberg School of Public Health (JHSPH). The JHSPH, founded in 1916, is the oldest and largest school of its kind. The School's legacy has and continues to be one of translating basic research into strategies to improve the public's health throughout the United States and the world. The eight floor North Wing was built in 1962 and houses a quarter of the School's laboratories dedicated to biomedical research. The scientific endeavor in the North Wing will be thematically organized around genetic, environmental, and host susceptibility risk factors in human disease. Research topics will include influenza and other infectious diseases, environmental hazards carried by air and water, malaria and other vector borne illnesses, reproductive disorders, and basic research on how the human genome responds to its environment. The mechanical, electrical, and plumbing infrastructure is approaching 50 years of age and has out-lived its useful life. Primary aims include: 1. Replace and upgrade the outmoded and deteriorated utility infrastructure of the facility to provide safe and reliable biomedical laboratory environments; 2. Renovate and modernize aged or obsolete laboratories to meet current and future needs while promoting collaboration among investigators using open and flexible laboratory design and layout; 3. Provide an incubator environment for promising young investigators by using spatial contiguity with laboratories of peers and more senior investigators; and, 4. Construct the School's first LEED-certified laboratory facilities. The North Wing's aging infrastructure and related decline in usability of the laboratories has been the School's number one capital project priority for the past five years but funding constraints have delayed it indefinitely. As a result of prior investment in consulting services and the preparation of construction documents, JHSPH is positioned to expeditiously undertake and complete this project well within the allocated time frame, and maintain and create professional and construction related jobs in the process. Partial cost-sharing is included to demonstrate institutional commitment. The enhanced infrastructure upgrades will improve the capacity, reliability and redundancy requirements of the utility systems while the renovations will improve the layout, finishes, and equipment needs associated with a modern laboratory research facility engaged in leading edge science. This project is key to enabling existing JHSPH investigators to remain competitive for funding and to the School's ability to recruit new high caliber scientific talent. This project will help ensure that JHSPH continues to pioneer discovery that promotes the public's health, both now and in the future.