Prospective Study of Cardiovascular Disease in End Stage Renal Disease (ESRD)

终末期肾病 (ESRD) 中心血管疾病的前瞻性研究

• 批准号: 7661574
• 负责人: MICHAEL J KLAG
• 金额: $ 11.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7661574
• 关键词: Affect; Age; Area; Arrhythmia; Arteries; Arts; Attention; Autonomic Dysfunction; Award; Baltimore; Blood Pressure; Calcium; Candidate Disease Gene; Cardiovascular Diseases; Cholesterol; Chronic Kidney Failure; Clinical; Clinical Trials; Cohort Studies; Coronary Arteriosclerosis; Coupled; Data; Death Rate; Diabetes Mellitus; Dialysis patients; Dialysis procedure; Disease; Echocardiography; End stage renal failure; Environment; Epidemic; Epidemiology; Event; Faculty; Family; Funding; Future; Gender; General Population; Genetic; Grant; Heart Diseases; Hemodialysis; High Prevalence; Incidence; Individual; Inflammation; Investigation; Kidney Diseases; Left Ventricular Function; Left Ventricular Hypertrophy; Longitudinal Studies; Magnesium; Manuscripts; Medicare; Mentors; Mentorship; Methods; Metric; Myocardial Infarction; Patients; Peer Review; Persons; Phenotype; Population; Potassium; Prevention; Prospective Studies; Public Health; Publishing; Race; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Project Grants; Research Training; Risk; Risk Factors; Serum; Time; Training; Training Programs; Variant; Ventricular; Ventricular Arrhythmia; Work; calcium phosphate; cardiovascular disorder risk; cardiovascular risk factor; cigarette smoking; cohort; design; experience; follow-up; genetic risk factor; heart rate variability; high risk; inflammatory marker; mortality; patient oriented research; prospective; sudden cardiac death

DESCRIPTION (provided by applicant): The U.S. is in the midst of an epidemic of chronic kidney disease. The incidence of treated end stage renal disease (ESRD) has risen every year since Medicare began collecting such information in 1973. In 2002, over 500,000 persons in the U.S. were treated for ESRD and about 20 million persons are estimated to have chronic kidney disease. Thus, chronic kidney disease is a major clinical and public health problem that demands our utmost attention. The present application is a renewal request for a K-24 award that the PI received in 2000. The PI is an established leader in the epidemiology and prevention of kidney disease who has an outstanding record of accomplishments in mentorship and conduct of patient-oriented research. The focus of his work has been to understand better the reasons for the excess risk of cardiovascular disease in persons with treated ESRD and milder forms of kidney disease. During the last 4 years, the PI has mentored 19 trainees and junior faculty and published 51 articles, 43 of which are peer-reviewed manuscripts, 25 of which have mentees as first author. Mentorship is accomplished through a rigorous didactic training program coupled with a mentored research experience and intensive involvement in federally-funded research projects. Training takes place within a very rich research environment and trainees are supported through institutional training grants as well as individual grants. A number of research opportunities exist for trainees; this application details a new cohort study of 1,000 treated ESRD patients from the Baltimore area who will be followed for up to 4 years to determine risk factors (traditional cardiovascular disease, dialysis-related, and genetic risk factors) for sudden cardiac death (SCD). ESRD patients are at very high risk of SCD, equivalent to persons who are post-myocardial infarction. This study will not only provide data to reduce the risk of this untoward event but will also provide a rich infrastructure for future studies, including clinical trials, and for research training.

描述（由申请人提供）： 美国正处于慢性肾病的流行之中。自1973年医疗保险开始收集此类信息以来，治疗终末期肾病（ESRD）的发病率每年都在上升。2002年，美国有超过50万人接受了ESRD治疗，估计约有2000万人患有慢性肾病。因此，慢性肾脏疾病是一个重大的临床和公共卫生问题，需要我们给予最大的关注。 本申请是PI在2000年收到的K-24奖励的续期请求。PI是肾脏疾病流行病学和预防领域的公认领导者，在指导和开展以患者为导向的研究方面有着杰出的成就记录。他的工作重点是更好地了解接受治疗的ESRD和轻度肾脏疾病患者心血管疾病风险过高的原因。在过去的4年中，PI指导了19名学员和初级教师，并发表了51篇文章，其中43篇是同行评审的手稿，其中25篇是第一作者。导师制是通过一个严格的教学培训计划，再加上指导的研究经验和联邦资助的研究项目的密集参与。培训是在一个非常丰富的研究环境中进行的，学员通过机构培训赠款和个人赠款得到支助。 学员有许多研究机会;本申请详细介绍了一项新的队列研究，该研究对来自巴尔的摩地区的1,000名接受治疗的ESRD患者进行了长达4年的随访，以确定心源性猝死（SCD）的风险因素（传统心血管疾病、透析相关和遗传风险因素）。ESRD患者SCD的风险非常高，相当于心肌梗死后患者。这项研究不仅将提供数据，以降低这种不良事件的风险，而且还将为未来的研究提供丰富的基础设施，包括临床试验和研究培训。

项目成果

Renal rehabilitation and improved patient outcomes in Texas dialysis facilities.

德克萨斯州透析设施的肾脏康复和患者预后的改善。

• DOI: 10.1053/ajkd.2002.34517
• 发表时间: 2002
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation.
• 作者: Curtin,RobertaBraun;Klag,MichaelJ;Bultman,DaraC;Schatell,Dorian
• 通讯作者: Schatell,Dorian

The coming epidemic: hypertension in rural Kyrgyzstan, Central Asia.

即将到来的流行病：中亚吉尔吉斯斯坦农村地区的高血压。

• DOI: 10.1038/sj.jhh.1001791
• 发表时间: 2005
• 期刊: Journal of human hypertension.
• 作者: Young,JH;Parler,P;Bristol,B;Klag,MJ
• 通讯作者: Klag,MJ

Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and Diabetes.

长期储存后尿白蛋白、总蛋白和肌酐测定的可靠性：肾病和糖尿病的家庭调查。

• DOI: 10.2215/cjn.01030207
• 发表时间: 2007
• 期刊: Clinical journal of the American Society of Nephrology : CJASN
• 作者: Parekh,RulanS;Kao,WHLinda;Meoni,LucyA;Ipp,Eli;Kimmel,PaulL;LaPage,Janine;Fondran,Carol;Knowler,WilliamC;Klag,MichaelJ;FamilyInvestigationofNephropathyandDiabetesResearchGroup
• 通讯作者: FamilyInvestigationofNephropathyandDiabetesResearchGroup