BSL-3/ABSL-3 Expansion for Select Agent Translational Research

用于选择药物转化研究的 BSL-3/ABSL-3 扩展

• 批准号: 7898025
• 负责人: WILLIAM M PIERCE
• 金额: $ 977.45万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-17 至 2015-02-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898025
• 关键词: Animal Model; Animals; Area; Certification; Clinical; Docking; Emergency medical service; Equipment; Evaluation; Evaluation Studies; Ferrets; Fire - disasters; Future; Growth; Hematology; Image; Laboratories; Life; Medicine; Monitor; Oryctolagus cuniculus; Procedures; Quarantine; Research Infrastructure; Rodent; Security; Services; Site; Sterilization; System; Translational Research; Universities; Vaccination; Water; Work; design; translational study

DESCRIPTION (provided by applicant): The University of Louisville proposes to expand the existing Center for Predictive Medicine (CPM) Regional Biocontainment Laboratory (RBL) to support work with select agents utilizing rodents, rabbits and ferrets as animal models in long term efficacy/product evaluation studies. The expansion will facilitate translational studies with the addition of hematology, clinical and whole-animal imaging services and related services for efficacy/product evaluation. Further, the expansion will provide receiving, quarantine and vaccination space in ABSL2 prior to animal studies transfer to ABSL3. ABSL2/3 animal holding areas and BSL3 support labs will be developed as suites with shared procedure and exam spaces. These suites will take advantage of existing trimodal live animal imaging capacities within the CPM and other existing support services. Importantly, the expansion will provide infrastructure for GLP studies with the Provantis(tm) system or other similar types of validated monitoring systems. The existing RBL was designed and built with infrastructure that will easily accommodate this future growth. Existing utilities (electrical, sanitary sewer, storm sewer, water service, fire service, emergency power) are sized and installed to accommodate expansion. Existing animal cage and rack wash and sterilization equipment within the existing CPM can accommodate this additional capacity. Security infrastructure (internal to facility and site fencing, setbacks and intrusion barriers) loading dock and service areas will be installed. All are adequate for expanded capacity. Site capacity for expansion is also accommodated and the existing facility is designed to attain LEED certification. This will permit the expansion to also achieve LEED certification and be in step with other sustainability initiatives set forth by the University of Louisville.

描述（由申请人提供）：路易斯维尔大学提议扩大现有的预测医学中心（CPM）区域生物防护实验室（RBL），以支持在长期疗效/产品评价研究中使用啮齿动物、兔子和雪貂作为动物模型的选定药剂的工作。此次扩展将促进转化研究，增加血液学、临床和整体动物成像服务以及用于疗效/产品评价的相关服务。此外，在动物研究转移至ABSL 3之前，扩展将在ABSL 2中提供接收、检疫和疫苗接种空间。ABSL 2/3动物饲养区和BSL 3支持实验室将开发为具有共享程序和检查空间的套房。这些套房将利用CPM和其他现有支持服务中现有的三模式活体动物成像能力。重要的是，扩展将为使用Provantis（TM）系统或其他类似类型的经验证的监测系统进行GLP研究提供基础设施。现有的RBL设计和构建的基础设施将轻松适应未来的增长。现有公用设施（电气、污水、雨水、供水、消防、应急电源）的大小和安装应适应扩建。现有CPM内的现有动物笼和架子清洗和灭菌设备可以容纳这种额外的容量。将安装安全基础设施（设施和现场围栏、后退和入侵屏障的内部）、装卸码头和服务区。所有这些都足以满足扩大的能力。扩建的场地容量也得到了满足，现有设施的设计旨在获得LEED认证。这将使扩建也能获得LEED认证，并与路易斯维尔大学提出的其他可持续发展倡议保持一致。