Center of Predictive Medicine for Biodefense

生物防御预测医学中心

• 批准号: 7005601
• 负责人: WILLIAM M PIERCE
• 金额: $ 2194.52万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7005601
• 关键词: behavioral /social science research tag; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; cooperative study; emerging infectious disease; host organism interaction; interdisciplinary collaboration; medicine; proteomics

DESCRIPTION (provided by applicant): The University of Louisville proposes to establish a Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPMBEID). Our long-term objective is to support the development of gene-based countermeasures and diagnostic approaches based on system changes that occur during host-pathogen interactions. Focusing on host-based bio-threat and emerging infectious disease research should allow the development of broad-spectrum interventions to infectious agents rather than the current paradigm of "one bug/one vaccine" approach so prevalent today. Our specific aims are to 1) meet the expanding needs of current researchers who work with Category A, B, or C priority pathogens at the University of Louisville; 2) expand facilities so that we can add an additional six faculty investigators who work with these agents; 3) assemble a unique mix of technologies in a free standing BSL3 facility so that the instrumentation and expertise is available on site to manipulate experimental materials and avoid the need for shipping material off site; and 4) to serve as a resource for investigators from other institutions in our region who can benefit from the unique mix of technologies we will assemble in the facility as well as be prepared to bring those technologies to bear in the event of a bioterrorism emergency. The University created a superb team of investigators and administrators to shepherd this project from application to operation. We are committed to working with NIAID and believe our missions can be mutually reinforced by building a RBL in Louisville.

描述（由申请人提供）： 路易斯维尔大学建议建立一个预测医学中心 生物性和新兴传染病（CPMBEID）。我们的长期目标是基于宿主 - 病原体相互作用期间发生的系统变化来支持基于基因的对策和诊断方法的发展。专注于基于宿主的生物威胁和新兴的传染病研究，应允许开发广谱干预措施来传染性药物，而不是当前的“一种错误/一种疫苗”方法的当前范式如此普遍。我们的具体目的是1）满足路易斯维尔大学与A，B类或C优先病原体合作的当前研究人员的不断扩展的需求； 2）扩展设施，以便我们可以增加与这些代理商合作的六位教师调查员； 3）在自由的BSL3设施中组装独特的技术组合，以便在现场可以使用仪器和专业知识来操纵实验材料，并避免需要将材料从现场运送出来； 4）为来自我们地区其他机构的调查人员提供资源，这些调查员可以从我们将在设施中组装的独特技术组合中受益，并准备在生物恐怖主义紧急情况下将这些技术带来耐用。该大学创建了一个由调查人员和管理人员组成的精湛团队，以从应用到操作。我们致力于与NIAID合作，并认为我们的任务可以通过在路易斯维尔建造RBL来相互加强。