Space Renovation for New Research Center for the Neglected Diseases of Poverty

被忽视的贫困疾病新研究中心的空间改造

• 批准号: 7877586
• 负责人: Jeffrey S Akman
• 金额: $ 1500万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-04 至 2014-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7877586
• 关键词: Address; Affect; African American; American; Area; Arts; Biomedical Research; Biotechnology; Certification; Chagas Disease; Commit; Complex; Cost Sharing; Diagnostic; Disadvantaged; Disease; District of Columbia; Employee; Epidemiology; Faculty; Foundations; Funding; Growth; Health Policy; Hispanic Americans; Home environment; Hookworms; Housing; Human; Individual; Infection; Journals; Life; Location; Occupations; Opisthorchiasis; Phase I Clinical Trials; Plants; Policies; Population; Poverty; Public Health; Recruitment Activity; Research; Research Personnel; Schistosomiasis; Scourge; Technology; Therapeutic; Toxocariasis; Toxoplasmosis; Translational Research; Tropical Disease; Underrepresented Minority; Universities; Vaccine Antigen; Vaccines; Vertebral column; Washington; Work; assault; cost; design; health disparity; medical schools; medical specialties; member; multidisciplinary; neglect; novel vaccines; product development; programs; research and development; research facility; square foot

DESCRIPTION (provided by applicant): The George Washington University ("GW") seeks funding to renovate approximately 25,400 net square feet of obsolete space to create a centrally located modern research complex for the new Research Center for the Neglected Diseases of Poverty in Washington, DC. The Research Center will conduct translational research for the development of new vaccines, therapeutics, and diagnostics for both neglected tropical diseases (NTDs), the devastating scourges of the "bottom billion"-the poorest people in the world who live on less than $1/day, and a unique group of neglected infections of poverty (NIPs) in the U.S. which have been recently recognized as one of the greatest health disparities affecting U.S. African American and Hispanic American populations. GW has launched a multifacted assault on these two groups of neglected diseases through its schools of medicine and public health, with faculty members conducting fundamental NIH-sponsored research on hookworm, schistosomiasis, opisthorchiasis, and toxoplasmosis, as well as epidemiological and policy work. GW is home to the Human Hookworm Vaccine Initiative (HHVI), a Gates Foundation-funded product development partnership (PDP) that is transitioning new vaccine antigens from discovery into Phase 1 trials. Also, extensive research is underway to study the major U.S. NIPs including toxocariasis, toxoplasmosis, and Chagas disease, currently affecting millions of African Americans and Hispanic Americans. A health policy initiative for both the NTDs and NIPs is also in progress at GW and we host the first open-access journal on these conditions, PLoS Neglected Tropical Diseases. While this research program at GW is strong, the physical plant that supports these investigators is so deficient it inhibits their co-location and growth of the program. This proposal aims to address these deficiencies by creating a state-of-the art research facility capable of housing the multidisciplinary researchers currently scattered across the University campus. The renovation project will employ green/sustainable technologies and design approaches, and will obtain LEED certification. All spaces will be ADA accessible. GW is fully committed to expanding the neglected diseases of poverty research program and demonstrates this through cost sharing 31% ($7.14M) of the building project costs, as well as recruiting new research-intensive tenured-track faculty in this area and creating an educational backbone for specialty biotechnology tracks and certificates for employees of the Research Center. This project will create or maintain at least 325 American jobs, with an intensive program to preferentially hire talented under-represented minority individuals from the District of Columbia and those with disadvantaged backgrounds. This project will transform and expand biomedical research at GW University, and the Research Center will significantly help address some of the greatest health disparities in the U.S. and around the world-the neglected infections of poverty and the neglected tropical diseases.

描述（由申请人提供）：该乔治华盛顿大学（“GW”）寻求资金，以翻新约25,400净平方英尺的陈旧空间，创造一个位于中心的现代化研究综合体的新研究中心被忽视的疾病的贫困在华盛顿，DC。该研究中心将开展转化研究，为被忽视的热带病（NTD）开发新的疫苗，治疗方法和诊断方法，这是“最底层十亿人”的毁灭性灾难-世界上每天生活费不到1美元的最贫穷的人，和一个独特的被忽视的贫困感染群体（NIP）最近被认为是影响美国非洲裔美国人和西班牙裔美国人人口的最大健康差距之一。GW通过其医学和公共卫生学院对这两组被忽视的疾病发起了多方面的攻击，教员们对钩虫，血吸虫病，后睾吸虫病和弓形虫病进行了基本的NIH赞助的研究，以及流行病学和政策工作。GW是人类钩虫疫苗计划（HHVI）的所在地，这是盖茨基金会资助的产品开发伙伴关系（PDP），正在将新疫苗抗原从发现过渡到1期试验。此外，正在进行广泛的研究，以研究美国的主要NIP，包括弓形虫病，弓形虫病和恰加斯病，目前影响着数百万非洲裔美国人和西班牙裔美国人。GW也在为NTD和NIP制定卫生政策计划，我们主办了第一份关于这些疾病的开放获取期刊《PLoS被忽视的热带疾病》。虽然GW的这项研究计划很强大，但支持这些研究人员的物理工厂非常缺乏，这抑制了他们的共同定位和计划的发展。该提案旨在通过创建一个能够容纳目前分散在大学校园内的多学科研究人员的最先进的研究设施来解决这些缺陷。改造项目将采用绿色/可持续发展技术和设计方法，并将获得LEED认证。所有空间都将是ADA无障碍的。GW完全致力于扩大被忽视的贫困疾病研究计划，并通过分摊31%（714万美元）的建筑项目成本来证明这一点，以及在这一领域招募新的研究密集型终身教职员工，并为研究中心的员工创建专业生物技术轨道和证书的教育骨干。该项目将创造或维持至少325个美国就业机会，并实施一项强化计划，优先雇用来自哥伦比亚特区的少数族裔人才和那些背景不利的人。该项目将改变和扩大GW大学的生物医学研究，研究中心将大大有助于解决美国和世界各地一些最大的健康差距-被忽视的贫困感染和被忽视的热带病。