Extramural Research Facilities Improvement Program

描述(由申请者提供)：麻省理工学院的动物资源计划是一项重要的资源，对该研究所的各种生物医学研究任务至关重要。这项提案寻求资金，以符合当前NIH和AAALAC标准的方式翻新和装备E25动物设施。E25是麻省理工学院集中动物资源计划的关键组成部分，该计划包括174,000 GSF空间，每天容纳104,000只动物。本提案记录了以下具体目标。 具体目标1：广泛翻新和扩建已有25年历史的现有动物设施E25，包括16,430个GSF和11,105个NSF可用住房、程序、手术和隔离空间，以便继续进行涉及多种动物的生物医学研究。 具体目标2：为E25配备隧道洗涤器、床上用品分配器和真空处理系统、通风的啮齿动物住所和老鼠转运站，以最大限度地提高空间和人员效率，并保护小鼠免受传染性鼠类病原体的感染。 具体的改进与麻省理工学院动物资源计划的长期目标直接相关，该计划旨在为NIH和其他来源支持的科学研究提供尽可能好的环境，同时保持AAALAC认证，并确保对实验动物的人文关怀和使用的最高标准。

DESCRIPTION (provided by applicant): The Animal Resource Program at MIT represents a vital resource that is central to the various biomedical research missions of the Institute. This proposal seeks funds to renovate and equip the E25 animal facility in a manner consistent with current NIH and AAALAC standards. E25 is a critical component of the centralized MIT Animal Resource Program that encompasses 174,000 gsf of space housing 104,000 animals on a daily basis. The following specific aims are documented in this proposal. Specific Aim 1: To extensively renovate and expand an existing 25 year old animal facility, E25, comprising 16,430 gsf with 11,105 nsf of usable housing, procedural, surgical, and quarantine space to allow continuation of biomedical research involving multiple species of animals. Specific Aim 2: To equip E25 with a tunnel washer, bedding dispenser and vacuum disposal system, ventilated rodent housing and mouse transfer stations, to maximize space and personnel efficiency and protection of mice from acquiring infectious murine pathogens. The specific improvements are directly related to the long term goal of MIT's Animal Resource Program, which is to provide the best possible environment for scientific inquiry supported by NIH and other sources, concurrently maintain AAALAC accreditation, and ensure the highest standards of humane care and use of laboratory animals.