Molecular Biology of the Vasculature

脉管系统的分子生物学

• 批准号: 7058649
• 负责人: MICHAEL E MENDELSOHN
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058649
• 关键词: cell biology; meeting /conference /symposium; pancreatic islet transplantation; pancreatic islets; travel

The proposed meeting will be an integrated program on pancreatic islet developmental biology and pancreatic islet transplantation. Both areas are on the forefront of several scientific disciplines (developmental biology, stem cells, transcription factors, transplantation, cell biology, gene regulation, and diabetes) and are the subject of intense scientific investigation. Islet transplantation, an emerging therapy for diabetes, is severely hampered by the lack of a sufficient number of islets for transplantation. A major goal of work to understand pancreatic islet development is the generation of new islets from stem cells (adult or embryonic). Challenges relevant to both fields are an incomplete understanding of the mechanisms controlling normal islet development and function and lack of information about islet cell differentiation, survival, and function after transplantation. The proposed program will focus on these scientific challenges by reviewing progress in these rapidly expanding fields and discussing strategies to overcome these obstacles. The proposed program will fill a unique need in that prior scientific meetings have focused on one topic or the other and have not brought together the leaders in both fields. The planning committee, consisting of two investigators with expertise in islet transplantation and two with expertise in pancreatic islet development, has structured the program to foster interaction between scientists and thus accelerate progress in these scientific areas.

拟议的会议将是胰岛发育生物学和胰岛移植的综合项目。这两个领域都处于多个科学学科（发育生物学、干细胞、转录因子、移植、细胞生物学、基因调控和糖尿病）的前沿，并且是深入科学研究的主题。胰岛移植是一种新兴的糖尿病疗法，但由于缺乏足够数量的胰岛进行移植而受到严重阻碍。了解胰岛发育的一个主要目标是从干细胞（成体或胚胎）产生新的胰岛。与这两个领域相关的挑战是对机制的不完整理解 控制正常的胰岛发育和功能，但缺乏移植后胰岛细胞分化、存活和功能的信息。拟议的计划将通过审查这些快速扩展领域的进展并讨论克服这些障碍的策略来关注这些科学挑战。拟议的计划将满足一种独特的需求，因为之前的科学会议都集中在一个主题或另一个主题上，并且没有聚集两个领域的领导者。规划委员会由两名具有胰岛移植专业知识的研究人员和两名具有胰岛发育专业知识的研究人员组成，制定了该计划以促进科学家之间的互动，从而加速 这些科学领域的进展。