Diabetes Mellitus and the Control of Energy Metabolism

描述(由申请人提供)： 患2型糖尿病的人数惊人地增加，加上其治疗费用高得不成比例，促使人们加紧努力了解这种慢性疾病及其并发症的生理病理。基因表达谱、基因沉默、蛋白质组学和成像技术的应用为该疾病带来了丰富的新见解和新途径。线粒体功能在胰岛素抵抗的发病机制、胰岛素增敏剂的作用机制和糖尿病并发症的发生中的作用等方面的新进展令人振奋。其他重要的进展涉及脂肪细胞衍生因子的分泌和作用机制，如外周和中枢神经系统中的瘦素、脂联素和炎性细胞因子。这次会议的一个目标是将致力于胰岛素作用、糖尿病发病机制和并发症领域的科学家与致力于线粒体生物发生、能量代谢和分泌途径中的膜运输领域的科学家聚集在一起。会议将寻求将这些信息与来自人类的基因和蛋白质数据库以及啮齿动物、酵母、果蝇和线虫等模型系统相结合。此外，一半的会议将与正在进行的脂肪生成和肥胖会议一起举行，以最大限度地提高肥胖症、细胞能量稳态和胰岛素抵抗等高度相关问题之间的信息流。预计这次会议将导致这些领域的研究人员与化学和治疗学相关人员之间的合作努力。

DESCRIPTION (provided by applicant): The alarming increase in the number of individuals developing Type 2 Diabetes, together with the disproportionately high expense of its treatment has raised intensive efforts in understanding the physiopathology of this chronic disease and its complications. The application of technologies of gene expression profiling, gene silencing, proteomics and imaging have led to a wealth of new insights and avenues into this disease. New exciting developments relate to the role of mitochondrial function in the pathogenesis of insulin resistance, in the mechanism of action of insulin sensitizers and in the development of diabetic complications. Other important developments relate to the mechanisms of secretion and action of adipocyte-derived factors such as leptin, adiponectin, and inflammatory cytokines in the periphery and in the central nervous system. A goal of this meeting is to bring together scientists working in the fields of insulin action, diabetes pathogenesis and complications with scientists working in areas of mitochondrial biogenesis, energy metabolism and membrane trafficking in the secretory pathway. The meeting will seek to integrate this information with gene and protein databases from humans and model systems such as rodents, yeast, drosophila and C.elegans. In addition, half the sessions will be held jointly with the ongoing adipogenesis and obesity meeting, to maximize information flow between the highly interrelated problems of obesity, cellular energy homeostasis, and insulin resistance. Collaborative efforts between investigators in these areas and those involved in chemistry and therapeutics are envisioned to result from this meeting.