FASEB SRC on Glucose transport: Gateway for metabolic systems Biology

描述（由申请人提供）：简单的单糖葡萄糖是整个生物界能量和碳的主要来源。在哺乳动物中，葡萄糖的循环浓度维持在一个非常狭窄的临界范围内，葡萄糖水平的破坏是2型糖尿病的主要病理生理表现。此外，葡萄糖来源的能量被解析为特定的细胞功能，如生长、增殖和维持，而癌细胞的生长严重依赖于葡萄糖依赖的途径。葡萄糖转运领域已经取得了重大进展，例如葡萄糖转运体的原子结构的阐明，以及在临床环境中葡萄糖再摄取选择性抑制剂的产生和使用。然而，许多问题仍然存在，对疾病机制的进一步影响取决于在更广泛的能量代谢及其调节背景下理解葡萄糖转运。本申请为参加2013年FASEB科学研究会议“葡萄糖运输：代谢系统生物学的门户”的年轻研究人员寻求住房和旅行支持，2013年7月14日至19日，美国科罗拉多州Snowmass村。20年来，这个会议一直是参与葡萄糖转运研究的科学家们面对面讨论葡萄糖转运复杂问题的新发现、新出现的问题和新出现的实验方法及其巨大生理影响的最重要的机会。本次会议的具体目的是：1)整合不同的方法来理解葡萄糖转运和代谢在全身代谢复杂性和疾病的背景下；2)吸引新的研究者进入复杂而重要的葡萄糖和能量代谢领域。现代方法包括假设驱动和屏幕驱动的发现，后者涉及生成复杂的数据库和工具，以实现假设检验。此外，目前的能量代谢概念必须考虑到微生物组的多个基因组的影响，它们在人体内不同的生态位相互作用。从葡萄糖转运和能量代谢的原子机制到系统生物学，提出了八个会议，由每个领域经验丰富的主要研究人员主持。为了确保及时讨论新出现的信息，大约30%的计划将从摘要中选择，并且来自该领域代表性不足的群体的年轻研究人员和科学家的参与将受到青睐。

DESCRIPTION (provided by applicant): The simple monosaccharide glucose is the primary source of energy and carbon throughout the biological world. In mammals, the circulating concentration of glucose is maintained within a very narrow critical range, and disruption of glucose levels is the central pathophysiological manifestation of Type-2 diabetes. Moreover, glucose-derived energy is parsed into specific cellular functions such as growth, proliferation and maintenance, and cancer cell growth is critically dependent on glucose-dependent pathways. There has been major progress in the field of glucose transport, exemplified by the elucidation of the atomic structure of glucose transporters, and the generation and use of selective inhibitors of glucose reuptake in clinical settings. However, many questions remain, and further impact on disease mechanisms is contingent upon understanding glucose transport within the wider context of energy metabolism and its regulation. This application seeks support for housing and travel for young investigators to attend the 2013 FASEB Science Research Conference "Glucose transport: Gateway for Metabolic Systems Biology" July 14-19, 2013, Snowmass Village, Colorado, USA. For 20 years this conference has been the single most important opportunity for scientists involved in the study of glucose transport to meet face to face to discuss new findings, arising questions, and emerging experimental approaches to the complex problem of glucose transport and its vast physiological repercussion. The specific aims of this conference are 1) To integrate diverse approaches to understanding glucose transport and metabolism within the context of whole-body metabolic complexity and disease, and 2) To attract new investigators into the complex and important field of glucose and energy metabolism. Modern approaches include hypothesis-driven and screen-driven discovery, the later involving the generation of sophisticated databases and tools to enable hypothesis testing. In addition, current concepts of energy metabolism must account for the effects of multiple genomes of the microbiome, interacting at different niches within the human body. Eight sessions spanning from atomic mechanisms to systems biology of glucose transport and energy metabolism are proposed, chaired by experienced, leading investigators in each field. To insure timely discussion of emerging information, approximately 30 percent of the program will be chosen from abstracts, and participation by young investigators and scientists from groups underrepresented in the field will be favored.