TGF-Beta Superfamily: Signaling and Development

描述(申请人提供)：转化生长因子-β(转化生长因子-β)超家族是一个分泌蛋白的大家族，在人类发育和健康中发挥重要作用。转化生长因子-β信号成分的胚系突变已被证明与血管异常遗传性出血性毛细血管扩张症I型和II型，以及遗传性癌症易感综合征幼年性息肉结肠有关。转化生长因子-β信号的获得性改变导致许多疾病，包括炎症和免疫疾病、心血管疾病和癌症。发育、分子、细胞生物学和生物化学之间的密切相互作用极大地促进了对参与转化生长因子-β家族作用的信号通路的识别。在拟议的会议中，组织者将利用这些互动，并继续促进和促进在转化生长因子-β家族生物学各个领域工作的科学家之间的进一步互动。会议的主题将集中于整个转化生长因子-β超家族的发育生物学和生物化学，并描绘这些过程如何与人类疾病相关。会议将包括八次全体会议，每一次会议有四名发言者，一次专门讨论新调查人员较短发言的特别会议，以及两次海报会议。下午将留出自由观看海报，并鼓励调查人员之间的非正式互动。这将是美国实验生物学学会联合会(FASEB)主办的第三次两年一度的同名会议，将于2005年6月25日至30日在科罗拉多州的斯诺马斯举行。根据以往会议的出席情况和与会者的反馈，组织者预计这个版本将继续成功地团结对转化生长因子-β生物学各个方面感兴趣的研究人员。

DESCRIPTION (provided by applicant): The transforming growth factor-beta (TGF-beta) superfamily is a large family of secreted proteins that play important roles in human development and health. Germline mutations in TGF-beta signaling components have been shown to contribute to the vascular abnormality hereditary hemorrhagic telangiectasia type I and type II, and to the hereditary cancer predisposition syndrome juvenile polyposis coli. Acquired alterations in TGF-beta signaling contribute to numerous diseases, including inflammatory and immune diseases, cardiovascular disease, and cancer. Identification of the signaling pathways involved in TGF-beta family actions was greatly facilitated by the close interplay among developmental, molecular, cellular biology, and biochemistry. In the proposed conference, the organizers will draw on those interactions and continue to facilitate and foster further interactions among scientists working in various areas of TGF-beta family biology. The topics at the conference will focus on the developmental biology and biochemistry of the entire TGF-beta superfamily, and delineate how these processes relate to human disease. The conference will include eight plenary sessions with four speakers each session, a special session devoted to shorter talks by new investigators, and two poster sessions. Afternoons will be left free to observe posters and encourage informal interactions among investigators. This will be the 3rd biennial conference of the same title hosted by the Federation of American Societies of Experimental Biology (FASEB), and will be held in Snowmass, Colorado from 25 to 30, June 2005. Based on attendance at previous conferences and feedback from attendees, the organizers anticipate that this version will continue to be a success in uniting investigators interested in the various aspects of TGF-beta biology.