PharmGKB Experimental Biology Workshop 2005

PharmGKB 实验生物学研讨会 2005

• 批准号: 6939400
• 负责人: TIMOTHY S. TRACY
• 金额: $ 0.48万
• 依托单位: AMERICAN SOCIETY FOR PHARMACOLOGY EXP TH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6939400
• 关键词: chemical information system; molecular biology information system; pharmacogenetics; pharmacology; travel; workshop

DESCRIPTION (provided by applicant): Pharmacogenetics/pharmacogenomics research holds promise to improve drug therapy by allowing individualization of doses based on a patient's genetic profile, thus prospectively minimizing the potential for toxicity and adverse effects and maximizing the desired effect. Within the NIH-funded Pharmacogenetics Research Network, the PharmGKB (Pharmacogenetics and Pharmacogenomics Knowledge Base) database is a searchable, central repository for pharmacogenetics and pharmacogenomics research information that is available to the entire scientific community. However, a limited number of individuals outside of the network have taken advantage of the database's capabilities and even fewer have deposited information into the database. To address these issues, we will offer a symposium at the Experimental Biology '05 Annual Meeting entitled ""Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB) and the Scientific Community: An Interactive Workshop". The goal of this symposium is to utilize a "wireless interactive" format to allow potential users hands-on training on the utility of the PharmGKB database including data deposition and searching of the database for information. The audience for this symposium will be all attendees of EB '05 but most specifically, those of the American Society for Pharmacology and Experimental Therapeutics and the American Society for Biochemistry and Molecular Biology. The primary emphasis of the workshop will be a hands-on workshop involving attendees, using their own laptops with wireless networking, becoming familiar with using the database by navigating it themselves in an interactive manner. This will be followed by presentations from three researchers outside the network and new to the database sharing both their pharmacogenetic data (FMO polymorphisms, CYP2C9 variant kinetics and NAT- 2 adverse effects) and the experience of submitting these data to the database.

描述（由申请人提供）：药物遗传学/药物基因组学研究有望通过允许基于患者的遗传特征的个性化剂量来改善药物治疗，从而前瞻性地最大程度地减少了对毒性和不良影响的可能性，并最大程度地提高了所需效应。在NIH资助的药物遗传学研究网络中，PharmGKB（药物遗传学和药物基因组学知识库）数据库是一个可搜索的，可用于整个科学界的药物遗传学和药物基因组学研究信息的中心存储库。但是，网络以外的人数有限，已经利用了数据库的功能，甚至将信息存入数据库中。要解决这些问题，我们将在实验生物学'05年度会议上提供题为““药物遗传学和药物基础知识基础”（PharmGKB）和科学界的题为“互动研讨会”。该研讨会的目的是允许使用“无线互动”的培训，以培训iT的数据，以供应介绍“互动”，该互动式培训的目的是培训。该研讨会的信息将是EB '05的所有参与者，但最具体地说，美国的药理学和实验性治疗学会和美国生物化学和分子生物学学会的主要范围都会是使用无效的企业，这是一个实用的工作室。通过来自网络以外的三名研究人员的演讲以及数据库的新成员，共享其药物遗传学数据（FMO多态性，CYP2C9变体动力学和NAT-2-2不良影响），以及将这些数据提交给数据库的经验。