Composition, Properties and structure of Tooth Enamel

描述（由申请人提供）：本R13申请的目的是请求支持第七届牙釉质组成，性质和基本结构国际研讨会。本次研讨会将为牙釉质研究的最新进展提供一个国际论坛，在一个有利于开放、批判性和建设性辩论的环境中进行介绍。研讨会将于2005年4月10日至14日在马萨诸塞州布鲁斯特的海洋边缘度假村和高尔夫俱乐部举行。“珐琅第七届”研讨会建立在一系列成功的牙釉质国际研讨会的基础上，这些研讨会于1964年在伦敦开始，最后一次于1997年在加利福尼亚州的箭头湖举行。具体来说，本次研讨会旨在：1)批判性地讨论自1997年上次研讨会以来牙釉质研究取得的重大进展；2)促进对牙釉质特性及其在体内形成和破坏机制的进一步了解；3)激发新的想法，这些想法可能作为发展用于修复和/或再生牙釉质组织的新型仿生方法的基础，以及预防牙釉质腐烂的方案；4)鼓励新的研究者、少数民族、妇女和残疾人参与到不断发展的研究领域中来。拟议的研讨会最终将对加强这些领域的研究活动产生重大影响，并导致口腔健康的改善。研讨会将限制在100人以内，以最大限度地进行互动和批判性讨论。与之前的六次专题讨论会一样，研讨会论文集（包括同行评议的文章和讨论）将在一个特别的期刊版上发表。可能的会议主题包括：成釉细胞生物学；无机相；釉质矿化;成釉细胞基因产物；发展缺陷；进化和系统发育方面；和仿生学/组织工程。鉴于自上次牙釉质研讨会以来在这些领域取得的重大进展，以及与基质介导的牙釉质形成和牙釉质疾病（如龋齿）相关的机制，提议的研讨会是及时的。计划采用独特的方案形式，包括海报和简短的口头报告，然后是小组讨论，分为10个主题会议，以及两个主题演讲。建议作出具体努力，促进新调查员、少数民族调查员和女性调查员以及残疾人的参与。

DESCRIPTION (provided by applicant): The purpose of this R13 application is to request support for the Seventh International Symposium on the Composition, Properties and Fundamental Structure of Tooth Enamel. The proposed Symposium will provide an international forum for the presentation of the latest advances in dental enamel research within an environment conducive to open, critical and constructive debate. The Symposium will be held on April 10 - 14, 2005 at the Ocean Edge Resort and Golf Club in Brewster, Massachusetts. The "Enamel VII" Symposium builds upon a successful series of international symposia on tooth enamel that began in London in 1964, and last held at Lake Arrowhead, California in 1997. Specifically, the proposed Symposium is designed to: 1) critically address significant advances in enamel research that have taken place since the last symposium was held in 1997; 2) to promote a better understanding of the properties of tooth enamel and mechanisms of its formation and destruction in vivo; 3) to stimulate new ideas that may potentially serve as the basis for the development of novel biomimetic approaches for the repair and/or regeneration of the enamel tissue, as well as protocols for the prevention of enamel decay; and 4) to encourage the involvement of new investigators, minorities, women, and persons with disabilities in the growing area of research. The proposed Symposium should ultimately have a significant impact on enhancing research activities in these areas and lead to an improvement in oral health. The Symposium will be limited to 100 participants to maximize interactions and critical discussions. As with the six preceding symposia, the Proceedings of the Symposium (including peer-reviewed articles and discussions) will be published in a special journal edition. Probable session topics include: Ameloblast Cell Biology; The Inorganic Phase; Enamel Mineralization; Ameloblast Gene Products; Defects of Development; Evolutionary and Phylogenetic Aspects; and Biomimetics/Tissue Engineering. Given the significant advances that have occurred since the last Enamel symposium in these areas, as related to the mechanisms of matrix-mediated enamel formation and enamel disease (e.g. dental caries), the proposed Symposium is timely. A unique program format is planned, consisting of poster and brief oral presentations, followed by panel discussions, organized within 10 thematic sessions, along with two keynote presentations. Specific efforts are proposed to promote the inclusion of new, minority and female investigators, as well as persons with disabilities.