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STRUCTURE AND FUNCTION OF SURFACTANT APOPROTEINS

STRUCTURE AND FUNCTION OF SURFACTANT APOPROTEINS
表面活性剂脱蛋白的结构和功能
批准号：
8054533
负责人：
Samuel Hawgood
金额：
$33.8万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-01-01 至 2015-12-31
来源：
https://reporter.nih.gov/project-details/8054533
关键词：
AffectAlveolarAlveolar MacrophagesAmino AcidsAntigen PresentationAntigen-Presenting CellsAntigensApoproteinsAreaB-LymphocytesBackBindingBiochemical GeneticsBody SurfaceCD8-Positive T-LymphocytesCell CommunicationCell Surface ReceptorsCell surfaceCellsCollagenCytolysisDendritic CellsDevelopmentEndocytosisEndosomesEpithelial CellsEpitheliumExhibitsExposure toGenetic VariationGrantHeadHemagglutininHumanHuman GenomeHumoral ImmunitiesImmune responseImmune systemIn VitroInfectionInflammationInfluenzaInfluenza A virusInterferon Type ILaboratoriesLectinLungMembrane GlycoproteinsModelingMusN-terminalPositioning AttributeProteinsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated Protein DRecoveryRegulationResearch DesignResearch PersonnelResistanceRespiratory SystemRespiratory tract structureRoleSourceStructureSurfaceT cell responseT-LymphocyteVariantViralVirusVirus Diseasesbasechemokinecytokinecytotoxicin vivoinnovationinterestkillingsmeetingsmicroorganismmouse modelpathogenprogramsprotein structurerespiratoryresponsesurfactantuptakevaccination strategy

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中文摘要
翻译
该方案研究了一种参与保护粘膜的表面活性物质相关蛋白(SP-D) 防止表面感染和发炎。我们将研究蛋白质的结构如何与功能相关 以及人类基因组中常见的变异如何影响SP-D的免疫调节功能。这个 结果可能与新疗法的发展有关，包括新的疫苗接种策略。 PHS 398/2590(06/09版)第63页续格式页
英文摘要
This proposal studies a surfactant-associated protein (SP-D) involved in protecting mucosal surfaces from infection and inflammation. We will study how the structure of the protein is related to function and how common variations in the human genome affect the immuno-modulatory functions of SP-D. The results may relate to the development of new therapies including new vaccination strategies. PHS 398/2590 (Rev. 06/09) Page 63 Continuation Format Page
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ADMINISTRATION CORE
FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology
CORE A- ADMINISTRATIVE
Magnetic resonance imaging and velocity-encoded MRI of pulmonary arteries
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