Conference Proposal: Smooth Muscle

描述(由申请人提供)： 本申请请求为2006年7月29日至8月3日在科罗拉多州斯诺马斯举行的2006年FASE B平滑肌肉会议提供部分资金。这次会议是自1982年以来每3年举行一次的一系列非常成功的平滑肌会议中的第9次。FASE B平滑肌肉会议被广泛认为是平滑肌肉生物学领域的首要论坛。这些会议非常受欢迎，来自澳大利亚、亚洲、欧洲和北美的主要调查人员参加了会议。对于那些对心血管、呼吸、消化、泌尿和生殖生理学和病理生理学感兴趣的人来说，对平滑肌生物学的了解是至关重要的。将重点介绍在过去三年中取得快速进展的领域。这些领域包括：平滑肌发育生物学、新的活体成像技术、细胞骨架功能、蛋白质-蛋白质相互作用、结构生物学、通道生物学、亚细胞钙动力学、激酶和磷酸酶信号的分子机制以及细胞与细胞之间的通讯。在讨论新的转基因和基因敲除技术时，将强调这些领域的整合，以创建缺乏或具有缺陷信号分子的动物模型，并揭示与临床疾病状态的重要联系。由于许多平滑肌研究人员致力于研究特定的器官系统，并经常参加与这些器官系统的细节相关的社会会议，因此召开一次讨论与平滑肌肉的细胞和组织生物学相关的共同问题的全面的平滑肌会议是极其重要的。会议的形式特别有利于非正式讨论和形成新合作的机会。除了申请书中描述的编排好的讲座并组织成9个专题研讨会外，年轻研究人员的来稿将从提交的摘要中挑选出来，并作为口头陈述添加到研讨会中。2006年FASE B平滑肌肉会议将全面回顾最先进的平滑肌肉生物学，并为开始在该领域进行研究的科学家或对平滑肌肉功能有更广泛临床兴趣的临床研究人员提供一个密集的短期课程。非正式互动的广泛机会将使各级调查人员能够结识新同事，探索新的想法和技术，并发展新的合作。

DESCRIPTION (provided by applicant): This application requests partial funding of the 2006 FASEB Smooth Muscle Conference to be held from July 29-August 3rd, 2006 at Snowmass, Colorado. This conference is the 9th in a highly successful series of smooth muscle meetings that have been held every 3 years since 1982. The FASEB Smooth Muscle Conferences are widely regarded as the premier forum in the field of smooth muscle biology. The meetings have been extremely popular and attended by leading investigators from Australia, Asia, Europe and North America. An understanding of smooth muscle biology is vital to those interested in cardiovascular, respiratory, digestive, urological and reproductive physiology and pathophysiology. Presentations will be focused on areas where rapid progress has been made during the past 3 years. These will include smooth muscle developmental biology, new in vivo imaging technologies, cytoskeletal function, protein-protein interactions, structural biology, channel biology, subcellular Ca dynamics, molecular mechanisms of kinase and phosphatase signaling, and cell to cell communication. Integration of these areas will be emphasized in discussions of new transgenic and knockout technologies to create animal models lacking or having defective signaling molecules and which reveal important connections to clinical disease states. Because many smooth muscle investigators work on specific organ systems and frequently attend society meetings related to the specifics of those organ systems, a comprehensive smooth muscle meeting where common issues related to the cell and tissue biology of smooth muscles are discussed is extremely important. The format of the meeting is especially conducive to informal discussion and opportunities to form new collaborations. In addition to the programmed lectures described in the application and organized into 9 topical symposia, contributions from young investigators will be selected from the abstracts submitted and added to the symposia as oral presentations. The 2006 FASEB Smooth Muscle Conference will provide a comprehensive review of state-ofthe-art smooth muscle biology and constitute an intensive short course for scientists who are beginning investigations in the field or clinical investigators with broader clinical interests in smooth muscle function. The extensive opportunities for informal interactions will allow investigators at all levels to meet new colleagues, explore new ideas and techniques, and develop new collaborations.