Conference Proposal: Smooth Muscle

描述（由申请人提供）： 本申请要求2006年7月29日至8月3日在科罗拉多斯诺马斯举行的2006年FASEB平滑肌会议的部分资金。本次会议是自1982年以来每3年举行一次的非常成功的平滑肌会议系列中的第9次。FASEB平滑肌会议被广泛认为是平滑肌生物学领域的首要论坛。这些会议非常受欢迎，来自澳大利亚、亚洲、欧洲和北美的主要调查人员参加了会议。平滑肌生物学的理解是至关重要的心血管，呼吸，消化，泌尿和生殖生理学和病理生理学感兴趣的人。发言将侧重于在过去三年中取得迅速进展的领域。这些将包括平滑肌发育生物学，新的体内成像技术，细胞骨架功能，蛋白质-蛋白质相互作用，结构生物学，通道生物学，亚细胞钙动力学，激酶和磷酸酶信号传导的分子机制，以及细胞与细胞通讯。这些领域的整合将在新的转基因和基因敲除技术的讨论中得到强调，以创建缺乏或有缺陷的信号分子的动物模型，并揭示与临床疾病状态的重要联系。由于许多平滑肌研究人员研究特定的器官系统，并经常参加与这些器官系统的具体情况相关的社会会议，因此讨论与平滑肌细胞和组织生物学相关的常见问题的全面平滑肌会议极其重要。会议的形式特别有利于进行非正式讨论，并有机会形成新的合作。除了在申请中描述的计划讲座，并组织成9个专题研讨会，从年轻的研究人员的贡献将从提交的摘要中选择，并添加到专题研讨会作为口头陈述。2006年FASEB平滑肌会议将提供最先进的平滑肌生物学的全面审查，并为开始在该领域进行调查的科学家或对平滑肌功能有更广泛临床兴趣的临床研究者提供密集的短期课程。非正式互动的广泛机会将使各级调查人员能够结识新同事，探索新的想法和技术，并开展新的合作。

DESCRIPTION (provided by applicant): This application requests partial funding of the 2006 FASEB Smooth Muscle Conference to be held from July 29-August 3rd, 2006 at Snowmass, Colorado. This conference is the 9th in a highly successful series of smooth muscle meetings that have been held every 3 years since 1982. The FASEB Smooth Muscle Conferences are widely regarded as the premier forum in the field of smooth muscle biology. The meetings have been extremely popular and attended by leading investigators from Australia, Asia, Europe and North America. An understanding of smooth muscle biology is vital to those interested in cardiovascular, respiratory, digestive, urological and reproductive physiology and pathophysiology. Presentations will be focused on areas where rapid progress has been made during the past 3 years. These will include smooth muscle developmental biology, new in vivo imaging technologies, cytoskeletal function, protein-protein interactions, structural biology, channel biology, subcellular Ca dynamics, molecular mechanisms of kinase and phosphatase signaling, and cell to cell communication. Integration of these areas will be emphasized in discussions of new transgenic and knockout technologies to create animal models lacking or having defective signaling molecules and which reveal important connections to clinical disease states. Because many smooth muscle investigators work on specific organ systems and frequently attend society meetings related to the specifics of those organ systems, a comprehensive smooth muscle meeting where common issues related to the cell and tissue biology of smooth muscles are discussed is extremely important. The format of the meeting is especially conducive to informal discussion and opportunities to form new collaborations. In addition to the programmed lectures described in the application and organized into 9 topical symposia, contributions from young investigators will be selected from the abstracts submitted and added to the symposia as oral presentations. The 2006 FASEB Smooth Muscle Conference will provide a comprehensive review of state-ofthe-art smooth muscle biology and constitute an intensive short course for scientists who are beginning investigations in the field or clinical investigators with broader clinical interests in smooth muscle function. The extensive opportunities for informal interactions will allow investigators at all levels to meet new colleagues, explore new ideas and techniques, and develop new collaborations.