2006 Mutagenesis Gordon Conference

描述（由申请人提供）：申请资金用于支持科学家参加将于2006年8月6日至11日在罗德岛的Salve Regina大学举行的戈登诱变研究会议。2006年诱变会议将重点关注产生诱变中间体的机制，防止这些中间体固定为永久突变的各种修复机制，以及诱变过程的调节。选定的演讲者将是诱变领域的专家，会议将通过每天上午/晚上的公开讨论以及下午的海报展示，成为所有参与者之间广泛互动的论坛。参加人数将限制在135人以内，并将努力鼓励少数群体、妇女、研究生和残疾人参加。会议将在第一个晚上开幕，有两个主题演讲，随后将有八个会议，重点是(i) DNA合成的保真度，（ii）微生物诱变机制，（iii）病变旁路机制，（iv）转录对遗传稳定性的影响，(v)程序诱变机制，（vi）产生染色体突变的机制，（vii）诱变过程的调节以及（viii）诱变与人类疾病之间的关系。诱变领域对人类健康至关重要，突变引发并促进了许多人类疾病的发展，特别是癌症和神经退行性疾病。此外，诱变过程在控制宿主-寄生虫相互作用中很重要，氧化损伤的积累与衰老有关。

DESCRIPTION (provided by applicant): Funds are requested to support scientists attending the Gordon Research Conference on Mutagenesis to be held August 6-11, 2006, at Salve Regina University in Rhode Island. The 2006 Mutagenesis Conference will focus on the mechanisms that generate mutagenic intermediates, on the diverse repair mechanisms that prevent the fixation of such intermediates as permanent mutations, and on the regulation of mutagenic processes. Selected speakers will be experts in the field of mutagenesis, and the meeting will serve as a forum for extensive interactions among all participants through open discussions within each morning/evening session as well as afternoon poster presentations. Attendance will be limited to 135 participants, and efforts will be made to encourage the attendance of minority groups, women, graduate students, and persons with disabilities. The conference will open on the first evening with two keynote addresses and this will be followed by eight sessions focusing on (i) the fidelity of DNA synthesis, (ii) mechanisms of microbial mutagenesis, (iii) mechanisms of lesion bypass (iv) effects of transcription on genetic stability, (v) mechanisms of programmed mutagenesis, (vi) mechanisms that generate chromosomal mutations, (vii) the regulation of mutagenic processes and (viii) the relationship between mutagenesis and human disease. The field of mutagenesis is critical to human health, with mutations initiating and facilitating the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases. In addition, mutagenic processes are important in controlling host-parasite interactions, and the accumulation of oxidative damage has been implicated in aging.