2004 Mutagenesis Gordon Conference

描述（由申请人提供）：申请资金用于支持参加第14届两年一度的戈登诱变研究会议的科学家的旅费和/或会议费，该会议将于2004年9月12日至17日在英国牛津大学女王学院举行。 会议将侧重于诱变和DNA修复的基本机制，并将强调突变在进化过程和人类疾病方面的生物学意义。 选定的发言者将是诱变领域的专家，会议将作为一个论坛，通过每次会议的公开讨论以及海报展示，使所有与会科学家进行广泛的互动。会议的报名通常严重超额，出席人数限制在135人。 将作出具体努力并特别考虑鼓励少数群体、妇女、研究生和残疾人参加。 会议将在第一个晚上开幕，有两个主题演讲，将提供诱变领域的历史观点。 随后将举行八次正式的上午/晚上会议，重点是：（i）诱变系统，（ii）超变序列，（iii）突变机制，（iv）突变避免系统，（v）人类遗传性和传染性疾病中的突变，（vi）进化中的突变率和基因型-表型关系，（vii）生态学，诱变和进化建模和（viii）人类群体的遗传多样性和人类诱变模型。 会议结束时将举行主旨演讲，综合介绍会上提出的成果和想法。 诱变领域对人类健康至关重要，因为突变引发并促进多种人类疾病的进展，特别是癌症和神经退行性疾病。 此外，致突变过程在控制宿主-寄生虫相互作用中很重要，氧化损伤的积累与衰老有关。

DESCRIPTION (provided by applicant): Funds are requested to support travel and/or conference fees for scientists attending the 14th bi-annual Gordon Research Conference on Mutagenesis to be held at The Queen's College, Oxford, UK, September 12-17, 2004. The Conference will focus on the basic mechanisms of mutagenesis and DNA repair, and also will emphasize the biological implications of mutations in terms of evolutionary processes and human disease. Selected speakers will be experts in the field of mutagenesis, and the meeting will serve as a forum for extensive interactions among all attending scientists through open discussions within each session as well as poster presentations. The Conference is usually heavily oversubscribed, with attendance being limited to 135 participants. Specific efforts will be made and special consideration given to encouraging the attendance of minority groups, women, graduate students, and persons with disabilities. The conference will open on the first evening with two keynote addresses that will provide a historical perspective on the field of mutagenesis. This will be followed by eight formal morning/evening sessions focusing on: (i) mutagenic systems, (ii) hypermutable sequences, (iii) mechanisms of mutation, (iv) mutation avoidance systems, (v) mutation in human hereditary and infectious diseases, (vi) mutation rates in evolution and genotypephenotype relationships, (vii) ecology, mutagenesis and the modeling of evolution and (viii) genetic diversity of the human population and models for human mutagenesis. The Conference will close with a keynote lecture that will provide a synthesis of the results and ideas presented at the meeting. The field of mutagenesis is critical to human health because mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases. In addition, mutagenic processes are important in controlling host-parasite interactions, and the accumulation of oxidative damage has been implicated in aging.