FASEB Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors

描述（由申请人提供）： 核激素受体（NHRs）是后生动物中最丰富的一类转录调节因子，调节多种功能，如稳态，生殖，发育或代谢。NHR作为配体激活的转录因子发挥作用，从而在控制这些过程的信号分子和转录应答之间提供直接联系。由于NHRs结合小分子，可以很容易地通过药物设计进行修饰，并控制与癌症，骨质疏松症，糖尿病等重大疾病相关的功能，因此它们是有前途的药理学靶标。在国家人权机构领域，一个迅速增长的兴趣是其结构的动态。我们的目的是创建第一次会议，将NHR专家的注意力集中在他们研究的受体的动态结构性质上。这次会议的目的是集中讨论这一领域的研究。本次会议将汇集来自蛋白质生物物理学的专家，他们正在使用先进的生物物理技术研究蛋白质动力学，与那些从事NHR行动和NHR结构研究的专家一起，激发我们对NHR作为动态而不是静态结构的领域的思考。我们希望，这次会议将扩大对国家人权机构动态结构性质的理解，并为今后几年将结构转化为实际应用的研究提供知识和技术基础。本次会议的具体目标包括：i）将NHR专家与研究非NHR系统的蛋白质生物化学家聚集在一起。这将使NHR领域对思维和方法有深入的了解，否则会很模糊。（ii）增加认识到国家人权机构动态性质的国家人权机构领域科学家的人数，并鼓励更多地研究这一领域。特别是鼓励 弱势少数群体和妇女参与国家人权机构这一领域的工作。分享关于国家人权机构动态性质的新发现。本申请旨在为美国联合会寻求财政支持， 实验生物学学会（FASEB）关于核激素受体动态结构的夏季会议，将于2006年7月8日至13日在亚利桑那州图森市举行。本次会议的结构是为了提供一个跨学科互动的最佳机会，以及在我们的领域最当代和最有争议的问题的平衡论文。已经/将尽一切努力尽可能多地吸收妇女、处境不利的少数群体和年轻调查员群体的参与者。

DESCRIPTION (provided by applicant): Nuclear hormone receptors (NHRs), one of the most abundant classes of transcriptional regulators in metazoans, regulate diverse functions, such as homeostasis, reproduction, development, or metabolism. The NHRs function as ligand activated transcription factors, thus providing a direct link between signaling molecules that control these processes and transcriptional responses. As NHRs bind small molecules which can easily be modified by drug design, and control functions associated with major diseases such as cancer, osteoporosis, diabetes etc, they are promising pharmacological targets. A rapidly growing interest in the field of NHRs is the dynamics of their structures. It is our intent to create the first meeting that focuses the attention of NHR experts on the dynamic structural nature of the receptors they study. The purpose of this meeting is to focus on the research in this area. This meeting will bring together experts from protein biophysics, who are using advanced biophysical techniques to study protein dynamics, with those working on NHR action & NHR structural studies, to spur thinking in our field on NHRs as dynamic rather than static structures. We hope that this meeting will broaden understanding of the dynamic structural nature of NHRs and provide the intellectual and technical foundation for the coming years of research that will translate structure into practical applications. The specific aims of this meeting includes: i) to bring together NHR experts with protein biochemists studying non-NHR systems. This will give the NHR field insights on thinking and methods otherwise obscure. ii) to broaden the number of scientists in the NHR field who are aware of the dynamic nature of NHRs, and to encourage more study of this area. In particular, to encourage participation of disadvantage minorities and women in this area of NHR work. iii) to share new findings on the dynamic nature of NHRs. This application seeks financial support for the Federation of American Societies of Experimental Biology (FASEB) Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors, to be held from July 8-13, 2006 at Tucson, AZ. This conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced treatise on the most contemporary and contentious problems in our field. Every possible effort have been/will be made to include maximum possible number of participants from women, disadvantage minorities, and young investigators groups.