FASEB Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors

FASEB 核激素受体动态结构夏季会议

• 批准号: 7161308
• 负责人: E B THOMPSON
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161308
• 关键词: genetic regulation; meeting /conference /symposium; nuclear receptors; protein structure function; travel

DESCRIPTION (provided by applicant): Nuclear hormone receptors (NHRs), one of the most abundant classes of transcriptional regulators in metazoans, regulate diverse functions, such as homeostasis, reproduction, development, or metabolism. The NHRs function as ligand activated transcription factors, thus providing a direct link between signaling molecules that control these processes and transcriptional responses. As NHRs bind small molecules which can easily be modified by drug design, and control functions associated with major diseases such as cancer, osteoporosis, diabetes etc, they are promising pharmacological targets. A rapidly growing interest in the field of NHRs is the dynamics of their structures. It is our intent to create the first meeting that focuses the attention of NHR experts on the dynamic structural nature of the receptors they study. The purpose of this meeting is to focus on the research in this area. This meeting will bring together experts from protein biophysics, who are using advanced biophysical techniques to study protein dynamics, with those working on NHR action & NHR structural studies, to spur thinking in our field on NHRs as dynamic rather than static structures. We hope that this meeting will broaden understanding of the dynamic structural nature of NHRs and provide the intellectual and technical foundation for the coming years of research that will translate structure into practical applications. The specific aims of this meeting includes: i) to bring together NHR experts with protein biochemists studying non-NHR systems. This will give the NHR field insights on thinking and methods otherwise obscure. ii) to broaden the number of scientists in the NHR field who are aware of the dynamic nature of NHRs, and to encourage more study of this area. In particular, to encourage participation of disadvantage minorities and women in this area of NHR work. iii) to share new findings on the dynamic nature of NHRs. This application seeks financial support for the Federation of American Societies of Experimental Biology (FASEB) Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors, to be held from July 8-13, 2006 at Tucson, AZ. This conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced treatise on the most contemporary and contentious problems in our field. Every possible effort have been/will be made to include maximum possible number of participants from women, disadvantage minorities, and young investigators groups.

描述(由申请人提供)： 核激素受体(NHR)是后生动物中含量最丰富的转录调节因子之一，调节多种功能，如动态平衡、生殖、发育或新陈代谢。NHR的功能是配体激活的转录因子，因此在控制这些过程的信号分子和转录反应之间提供了直接的联系。由于NHR结合了易于通过药物设计进行修饰的小分子，并控制与癌症、骨质疏松症、糖尿病等重大疾病相关的功能，因此它们是很有前途的药理靶点。对国家人权机构领域迅速增长的兴趣是其结构的动态。我们的目的是创建第一次会议，将NHR专家的注意力集中在他们研究的受体的动态结构性质上。这次会议的目的是聚焦于这一领域的研究。这次会议将汇集来自蛋白质生物物理学的专家，他们正在使用先进的生物物理技术来研究蛋白质动力学，以及那些从事NHR行动和NHR结构研究的人，以促进我们领域对NHR作为动态结构而不是静态结构的思考。我们希望，这次会议将扩大对国家人权机构动态结构性质的理解，并为今后几年将结构转化为实际应用的研究提供智力和技术基础。这次会议的具体目的包括：i)将NHR专家和研究非NHR系统的蛋白质生物化学家聚集在一起。这将使NHR领域在其他方面晦涩难懂的思维和方法方面有更深入的了解。二)扩大国家人力资源领域了解国家人权机构动态性质的科学家人数，并鼓励对这一领域进行更多研究。特别是鼓励 处于不利地位的少数群体和妇女参与这一领域的国家人力资源工作。三)分享关于国家人权机构动态性质的新发现。本申请寻求美国联邦政府的财政支持。 实验生物学学会关于核激素受体动态结构的夏季会议，将于2006年7月8日至13日在亚利桑那州图森市举行。这次会议旨在为跨学科互动提供最佳机会，并就我们领域最当代和最具争议性的问题进行平衡的论述。已经/将尽一切可能的努力，尽可能多地包括来自妇女、弱势少数群体和年轻调查人员群体的参与者。