课题基金 / 基金详情

MECHANISMS OF GROWTH CONTROL BY STEROIDS

MECHANISMS OF GROWTH CONTROL BY STEROIDS
类固醇的生长控制机制
批准号:
3095640
负责人:
E B THOMPSON
金额:
$51.47万
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-03-04 至 1994-02-28

项目摘要

项目成果

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中文摘要
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英文摘要
This proposed program project focuses upon regulation of cell proliferation by steroid hormones. Three projects are proposed that deal with different aspects of the manner in which glucocorticoids, estrogens, and sterols regulate proliferation. Although the projects deal almost entirely with malignant cells, the phenomena to be investigated have direct relevance to regulatory processes that are common to growth control in both transformed and normal cells. The central hypothesis to be explored proposes that these compounds play a critical role in the neoplastic transformation and maintenance of the proliferative state. The individual projects address regulation of human lymphoid cells by oxysterols and glucocorticoids (Projects I and II) and mechanisms of estrogen induction of renal tumors in hamster kidneys (Project III).
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Elevation of protooncogene messenger RNAs in estrogen-induced kidney tumors in the hamster.
雌激素诱导的仓鼠肾肿瘤中原癌基因信使 RNA 的升高。
DOI: 10.1093/carcin/13.4.601
发表时间: 1992
期刊: Carcinogenesis
影响因子: 4.7
作者: [Liehr,JG, Chiappetta,C, Roy,D, Stancel,GM]
通讯作者: Stancel,GM
Oxysterol-induced cell death in human leukemic T-cells correlates with oxysterol binding protein occupancy and is independent of glucocorticoid-induced apoptosis.
人类白血病 T 细胞中氧甾醇诱导的细胞死亡与氧甾醇结合蛋白的占据相关,并且与糖皮质激素诱导的细胞凋亡无关。
DOI: 10.1016/0960-0760(93)90096-f
发表时间: 1993
期刊: The Journal of steroid biochemistry and molecular biology
影响因子: --
作者: [Bakos,JT, Johnson,BH, Thompson,EB]
通讯作者: Thompson,EB
Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA.
氧甾醇敏感和耐药淋巴细胞:与细胞核酸结合蛋白 mRNA 调节的相关性。
DOI: 10.1016/0960-0760(94)90070-1
发表时间: 1994
期刊: The Journal of steroid biochemistry and molecular biology
影响因子: --
作者: [Ayala-Torres,S, Johnson,BH, Thompson,EB]
通讯作者: Thompson,EB
Multidisciplinary Training in Cancer Research
Multidisciplinary Training in Cancer Research
Multidisciplinary Training in Cancer Research
FASEB Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors
海外基金