MECHANISMS OF GROWTH CONTROL BY STEROIDS

这个计划项目的重点是调节细胞增殖 类固醇激素的作用 提出了三个项目，处理不同的 糖皮质激素、雌激素和甾醇类 规范扩散。 尽管这些项目几乎全部涉及 恶性细胞，待研究的现象与以下直接相关： 调节过程是共同的生长控制，在两个转化 正常细胞。 待探讨的中心假设提出， 这些化合物在肿瘤转化中起关键作用， 维持增殖状态。 个别项目地址 氧固醇和糖皮质激素对人淋巴细胞的调节作用 （项目I和II）和肾肿瘤的雌激素诱导机制， 仓鼠肾（项目III）。

This proposed program project focuses upon regulation of cell proliferation by steroid hormones. Three projects are proposed that deal with different aspects of the manner in which glucocorticoids, estrogens, and sterols regulate proliferation. Although the projects deal almost entirely with malignant cells, the phenomena to be investigated have direct relevance to regulatory processes that are common to growth control in both transformed and normal cells. The central hypothesis to be explored proposes that these compounds play a critical role in the neoplastic transformation and maintenance of the proliferative state. The individual projects address regulation of human lymphoid cells by oxysterols and glucocorticoids (Projects I and II) and mechanisms of estrogen induction of renal tumors in hamster kidneys (Project III).