MECHANISMS OF GROWTH CONTROL BY STEROIDS

类固醇的生长控制机制

• 批准号: 3095640
• 负责人: E B THOMPSON
• 金额: $ 51.47万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-04 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3095640
• 关键词: hormone regulation /control mechanism; neoplastic growth; steroids

This proposed program project focuses upon regulation of cell proliferation by steroid hormones. Three projects are proposed that deal with different aspects of the manner in which glucocorticoids, estrogens, and sterols regulate proliferation. Although the projects deal almost entirely with malignant cells, the phenomena to be investigated have direct relevance to regulatory processes that are common to growth control in both transformed and normal cells. The central hypothesis to be explored proposes that these compounds play a critical role in the neoplastic transformation and maintenance of the proliferative state. The individual projects address regulation of human lymphoid cells by oxysterols and glucocorticoids (Projects I and II) and mechanisms of estrogen induction of renal tumors in hamster kidneys (Project III).

这个计划项目的重点是细胞增殖的调控。 由类固醇激素引起的。提出了三个项目，分别处理不同的 糖皮质激素、雌激素和甾醇的作用方式 控制扩散。尽管这些项目几乎全部涉及 恶性细胞，要研究的现象与 在这两个国家都有共同的增长控制监管过程 和正常细胞。将要探索的中心假说提出 这些化合物在肿瘤转化和转移中起着关键作用。 维持增殖状态。个别项目涉及 氧化甾醇和糖皮质激素对人淋巴样细胞的调节 (方案I和II)和雌激素诱导小鼠肾脏肿瘤的机制 仓鼠肾脏(项目III)。

项目成果

Elevation of protooncogene messenger RNAs in estrogen-induced kidney tumors in the hamster.

雌激素诱导的仓鼠肾肿瘤中原癌基因信使 RNA 的升高。

• DOI: 10.1093/carcin/13.4.601
• 发表时间: 1992
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Liehr,JG;Chiappetta,C;Roy,D;Stancel,GM
• 通讯作者: Stancel,GM

Oxysterol-induced cell death in human leukemic T-cells correlates with oxysterol binding protein occupancy and is independent of glucocorticoid-induced apoptosis.

人类白血病 T 细胞中氧甾醇诱导的细胞死亡与氧甾醇结合蛋白的占据相关，并且与糖皮质激素诱导的细胞凋亡无关。

• DOI: 10.1016/0960-0760(93)90096-f
• 发表时间: 1993
• 期刊: The Journal of steroid biochemistry and molecular biology
• 作者: Bakos,JT;Johnson,BH;Thompson,EB
• 通讯作者: Thompson,EB

Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA.

氧甾醇敏感和耐药淋巴细胞：与细胞核酸结合蛋白 mRNA 调节的相关性。

• DOI: 10.1016/0960-0760(94)90070-1
• 发表时间: 1994
• 期刊: The Journal of steroid biochemistry and molecular biology
• 作者: Ayala-Torres,S;Johnson,BH;Thompson,EB
• 通讯作者: Thompson,EB