MECHANISMS OF GROWTH CONTROL BY STEROIDS

类固醇的生长控制机制

• 批准号: 3095637
• 负责人: E B THOMPSON
• 金额: $ 41.23万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-04 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3095637
• 关键词: hormone regulation /control mechanism; neoplastic growth; steroids

This proposed program project focuses upon regulation of cell proliferation by steroid hormones. Three projects are proposed that deal with different aspects of the manner in which glucocorticoids, estrogens, and sterols regulate proliferation. Although the projects deal almost entirely with malignant cells, the phenomena to be investigated have direct relevance to regulatory processes that are common to growth control in both transformed and normal cells. The central hypothesis to be explored proposes that these compounds play a critical role in the neoplastic transformation and maintenance of the proliferative state. The individual projects address regulation of human lymphoid cells by oxysterols and glucocorticoids (Projects I and II) and mechanisms of estrogen induction of renal tumors in hamster kidneys (Project III).

这个计划项目的重点是细胞增殖的调节