2006 Environmental Endocrine Disruptors Gordon Conference

描述（由申请人提供） 第五届戈登环境内分泌干扰物研究会议将于2006年6月4日至9日在意大利的II Ciocco举行。本次会议的目的有两个：第一，纪念意大利塞维索工业二恶英事故30周年，这是一场导致人类内分泌系统严重破坏的环境灾难;第二，通过讨论基础研究中内分泌干扰物、野生动物和人类之间重叠的细胞信号传导途径，突出最新的科学。演讲者将包括来自美国、日本和欧洲的顶尖科学家，以及最近报告了令人兴奋的发现的年轻科学家。目前认为，内分泌干扰物不仅影响男性和女性生殖系统的发育，而且还涉及许多器官系统的发育和成年功能，并可能在某些类型癌症的发病中发挥作用。美国、日本和欧盟政府已经颁布了管理内分泌干扰物的法律，在美国，通过了《安全饮用水法》和《食品质量保护法》修正案，规定对水和食品中发现的化学品进行内分泌干扰活性测试。戈登研究会议（GRC）是一个很好的场所，以促进研究在这一重要领域的研究，因为它是GRC的指导原则，介绍是新的，未发表的工作，讨论是开放和不受阻碍的。有一种在“非正式”气氛中自由交流想法的传统，不发表会议记录。这一基本理念非常重要，因为所提出的主题处于科学的前沿，例如关于表观遗传学的拟议会议。这次会议涉及一个跨学科的主题，因此将汇集一批不同的国际科学家，他们的研究范围从人类的主题，如二恶英暴露的情况下，野生动物，以及在建立动物模型和新的体外系统的基础研究。除了NIEHS，这次会议是潜在的兴趣，老龄化研究所（NIA）。2006年的方案将包括关于二恶英、表观遗传学、细胞信号串扰、受体介导的内分泌干扰、动物实验和人体接触的比较、代谢综合征、低剂量和J形效应以及干细胞的会议。

DESCRIPTION (provided by applicant) The fifth Gordon Research Conference (GRC) on Environmental Endocrine Disruptors will be held June 4-9, 2006, in II Ciocco, Italy. This purpose of this conference is two fold; first to mark the 30th anniversary of the industrial dioxin accident in Seveso, Italy, an environmental disaster that has resulted in serious disruption of the human endocrine system; second, to highlight the most up-to-date science through discussions of cell signaling pathways that overlap between endocrine disrupters in basic research studies, wildlife and human populations. Speakers will include leading scientists from the US, Japan and Europe, as well as young scientists who have recently reported exciting findings. Endocrine disruptors are now thought to influence the development of not only male and female reproductive systems, but also to be involved in the development and adult functions of numerous organ systems, as well as potentially playing a role in the onset of certain types of cancers. Governments of the United States, Japan and the European Union have enacted laws regulating endocrine disrupters and in the U.S., amendments were passed to the Safe Drinking Water Act and the Food Quality Protection Act, mandating the testing of chemicals found in water and food for endocrine disrupting activity. The Gordon Research Conference (GRC) is an excellent venue for promoting research in this important area of study, as it is the guiding principle of the GRC that the presentations are to be of new, unpublished work and that the discussions are to be open and unhampered. There is a tradition of freely sharing ideas in an "off the record" atmosphere, without the publication of conference proceedings. This underlying philosophy is very important because the proposed topics are at the cutting edge of science, such as the proposed session on epigenetics. This conference deals with an interdisciplinary subject and as such will bring together a diverse group of international scientists, whose studies range from human subjects, as in the case of dioxin exposure, to wildlife, as well as basic research in established animal models and novel in vitro systems. In addition to the NIEHS, this conference is of potential interest to the Institute of Aging (NIA). The 2006 Program will include sessions on dioxin, epigenetics, cell signaling cross talk, receptor mediated endocrine disruption, comparison of animal experimentation and human exposures, the metabolic syndrome, low dose and J-shaped effects, and stem cells.