Malaria: Functional Genomics to Biology to Medicine

在过去的十年里，疟疾寄生虫的基础生物学知识爆炸式增长。基因组序列现已完成，寄生虫的分子遗传操作方法已可用，基因表达和蛋白质表达的详细描述正在汇编，对寄生虫基本生物学的研究大大提高了我们对该生物体的了解，但疟疾仍然是一个主要的世界卫生问题，每年有5亿多人感染，100万至300万人死亡，主要是非洲的儿童。本次会议将重点讨论寄生虫系统生物学的详细研究，包括种群生物学和遗传多样性，宿主寄生虫和寄生虫载体的相互作用， 包括免疫学，目的是为未来的干预确定新的见解。它将汇集寄生虫生物学专家和相关学科的专家，希望为药物和疫苗开发开发新的范例。

Knowledge in the basic biology of the malaria parasite has exploded over the past ten years. The genome sequence is now completed, methods for molecular genetic manipulation of the parasite are available, detailed descriptions of gene expression and protein expression are being assembled, and studies on the basic biology of the parasite have greatly enhanced our understanding of the organism yet, malaria remains a major world health problem with over 500 million people infected each year and one to three million deaths, primarily in children in Africa. This meeting will focus on a detailed examination of parasite systems biology, including population biology and genetic diversity, host parasite and parasite vector interactions, including immunology with to goal of identifying new insights for future intervention. It will bring together experts in parasite biology with experts in related disciplines with the hopes of developing new paradigms for drug and vaccine development.