ANIMAL HEALTH RESOURCES IMPROVEMENT PROJECT

描述（由申请人提供）：弗雷德哈钦森癌症研究中心（FHCRC）汇集了200多名在基础，临床和公共卫生科学研究兴趣的FHCRC教师。为了保持与同行机构的竞争力，FHCRC必须能够满足动物健康资源（AHR）对新教师和现有项目增长的空间需求。目前，FHCRC南湖联盟有79名研究人员在现有设施内的大约200个有效和批准的IACUC方案中使用动物进行研究计划。在过去的4个财政年度中，AHR部门的护理天数增加了约69%，其中大部分增加主要是由于现有教师中转基因啮齿动物的使用范围扩大。增加新的教师到FHCRC和扩大目前的调查人员的需求，预计将有助于这一趋势的延续。FHCRC目前正在完成对其啮齿动物种群进行单独通风和HEPA过滤笼的初步过渡，这将允许在现有设施空间内增加其动物种群的饲养密度。目前，随着通风机架容量的不断安装和扩展，需要满足不断增长的需求。申请的资金用于购买17个双面和19个单面通风机架系统及相关配件。要求的额外机架将使我们能够最大限度地提高现有设施内的动物饲养密度，为所有依赖小鼠模型进行癌症相关研究项目的中心教师提供益处。有全面和补充的动物设施使用程序，结合通风笼舍，解决所有使用区域的人员和物料流动，以排除可能危及动物健康和科学质量的啮齿动物病原体。

DESCRIPTION (provided by applicant):The Fred Hutchinson Cancer Research Center (FHCRC) brings together more than 200 FHCRC faculty with research interests in basic, clinical and public health sciences. To remain competitive with peer institutions, the FHCRC must be capable of accommodating the Animal Health Resource (AHR) space needs for new faculty and growth in the existing programs. There are presently 79 investigators on the FHCRC South Lake Union utilizing animals in approximately 200 active and approved IACUC protocols for their programs of study within the existing facilities. The AHR department has experienced an approximate 69% increase in care days over the past 4 fiscal years, with most of the increase principally due to expanding use of genetically modified rodents among existing faculty. Addition of new faculty to the FHCRC and expanding needs of current investigators are expected to contribute to a continuation of this trend. The FHCRC is currently completing an initial transition to individually ventilated and HEPA filtered caging for its rodent colonies, which will allow increased housing density within existing facility space for its animal populations. Currently there is a need to meet the growing demand, with continued installation and expansion of ventilated rack capacity. Funding is requested for the purchase of 17 double faced and 19 single faced ventilated rack systems with associated accessories. The additional racks requested will allow us to maximize animal housing densities within the existing facility, providing benefit to all Center faculty who rely upon mouse models for their cancer related research projects. There are comprehensive and complementary animal facility use procedures in conjunction with the ventilated caging that address personnel and material flow in all areas of use to provide for exclusion of rodent pathogens which could jeopardize animal health and scientific quality.