UNIVERSITY OF SOUTH FLORIDA MOUSE BARRIER FACILITY

南佛罗里达大学老鼠屏障设施

• 批准号: 6762591
• 负责人: MICHAEL. IAN PHILLIPS
• 金额: $ 63.83万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2005-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6762591
• 关键词: animal colony; biomedical facility; building /facility design /renovation; laboratory mouse

DESCRIPTION (provided by applicant): Support is requested for movable equipment critically needed in the University's new Moffitt Mouse Barrier Facility, scheduled for occupancy in June 2004. This new facility was established in response to a 733% increase in animal care and use service demands since 1996, due principally to a 1,068% increase in the number of genetically engineered mice. Capacities of the four existing animal facilities of this centrally administered, AAALAC accredited program in Tampa Bay had been exceeded, and all lacked a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The new mouse facility is ideally located near the greatest focus of federally funded research involving mice, and adjacent to the largest research laboratory expansion in Tampa Bay history. Located on the ground level of the new Vincent A. Stabile Research Building of the University-affiliated H. Lee Moffitt Cancer Center and Research Institute, this new 27,683 nsf facility will establish 6,231 nsf of additional mouse housing space, a dedicated laboratory for the Mouse Models Core, a dedicated necropsy for the Mouse Pathology Core, and a suite of laboratories for the In Vivo Mouse Imaging Core, all in a setting of stringent microbiological security. With occupancy of this new facility, more than 12,600 microisolators will be needed to house between 37,800 and 52,500 additional mice. Support is requested to purchase 22% of the needed mouse microisolators, or 31 mouse microisolator ventilated racks, and 5 associated cage-changing stations. Strong institutional support for this proposal is demonstrated by the University's commitment to purchase the balance of the 140 mouse microisolator racks, and 22 animal transfer stations needed for this new mouse facility, an investment match of 3.6 to 1. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight neighboring institutions that will use this new regional resource.

描述（由申请人提供）： 要求支持该大学新的Moffitt Mouse屏障设施所需的可移动设备，该设施计划于2004年6月占用。该新设施是为了响应自1996年以来的动物护理和使用服务需求增长733％，这主要是由于主要归因于1,068％的基因工程小鼠的数量增加了1,068％。该集中管理的四个现有动物设施的能力已超过了坦帕湾的AAAALAC认证计划，并且所有这些计划都缺乏安全的微生物屏障，这使研究有可能因感染而被无效。新的小鼠设施理想地位于涉及小鼠的联邦资助研究的最大重点附近，毗邻坦帕湾历史上最大的研究实验室扩张。 Located on the ground level of the new Vincent A. Stabile Research Building of the University-affiliated H. Lee Moffitt Cancer Center and Research Institute, this new 27,683 nsf facility will establish 6,231 nsf of additional mouse housing space, a dedicated laboratory for the Mouse Models Core, a dedicated necropsy for the Mouse Pathology Core, and a suite of laboratories for the In Vivo Mouse Imaging Core, all in a setting of严格的微生物安全。随着这个新设施的占用，将需要12,600多个微分机来容纳37,800至52,500只小鼠。请求支持购买22％所需的鼠标微溶剂，或31个鼠标微型固定器通风架，以及5个相关的笼子改变架。大学承诺购买140个老鼠微型固定架的余额以及该新的鼠标设施所需的22个动物转移站的承诺证明了对该提案的强烈机构支持，这是3.6至1的投资匹配。所要求的可移动设备的净益处将累积由八个邻近机构使用的科学家使用该新区域的科学家研究，该公司将利用这个新的地区。