Improved Magnetic Resonance Imaging of Breast Cancer

改进乳腺癌的磁共振成像

• 批准号: 7114352
• 负责人: GLEN R MORRELL
• 金额: $ 14.01万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-19 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114352
• 关键词: breast neoplasm /cancer diagnosis; cell morphology; clinical research; clinical trials; diagnosis design /evaluation; diagnosis quality /standard; human subject; hyperplasia; image enhancement; magnetic resonance imaging; mammography; neoplasm /cancer classification /staging; phantom model

DESCRIPTION (provided by applicant): This is a career development grant proposal to enable Dr. Glen Morrell (the applicant) to develop a long term research program in the application of new methods of magnetic resonance imaging (MRI) of breast cancer. Dr. Morrell received a Ph.D. degree in Electrical Engineering from Stanford in 1998, researching novel methods for MRI. He then completed medical school at Stanford and a Diagnostic Radiology residency and fellowship in MRI at the University of Pennsylvania. He is now in his first year as Assistant Professor of Radiology at the University of Utah. His goal is to combine his knowledge of MRI physics and novel MRI techniques with the clinical practice of radiology, specifically in MRI of breast cancer. Despite the applicant's many years of education, he has had no postdoctoral training in electrical engineering, and has not had opportunity to apply techniques developed in his Ph.D. research to clinically relevant imaging problems. The requested support will allow Dr. Morrell to continue his education in aspects of physics and engineering related to medical imaging, and to continue to gain clinical expertise as a radiologist. During the five-year funding period, Dr. Morrell will apply techniques of multi-dimensional excitation from his Ph.D. research to improve breast MRI and validate these techniques through limited clinical trials. He will gain a greater understanding of quantum mechanics and other principles of physics directly relating to MRI with the aim of developing methods of spectroscopic imaging of the breast. He will be mentored in the design of clinical trials and the conduct of research. The expected benefit of the proposed research plan is improved detection of breast cancer and decreased number of invasive biopsies of benign breast lesions. Based on the pilot studies supported by this grant, Dr. Morrell will submit proposals for funding through R01 or similar mechanisms to maintain and expand a long term research program in MRI of breast cancer, collaborating with well established programs in oncology, pharmaceutics, and genetics at the University of Utah.

描述（由申请人提供）：这是一个职业发展补助金的建议，使格伦莫雷尔博士（申请人）制定一个长期的研究计划，在乳腺癌的磁共振成像（MRI）的新方法的应用。莫雷尔博士获得了博士学位。1998年在斯坦福大学获得电气工程学位，研究MRI的新方法。然后，他在斯坦福大学完成了医学院的学业，并在宾夕法尼亚大学获得了诊断放射学住院医师和MRI奖学金。他现在是犹他州大学放射学助理教授的第一年。他的目标是联合收割机结合他的MRI物理知识和新的MRI技术与放射学的临床实践，特别是在乳腺癌的MRI。尽管申请人接受了多年的教育，但他没有接受过电气工程方面的博士后培训，也没有机会应用他在博士学位上开发的技术。研究临床相关的成像问题。请求的支持将使莫雷尔博士能够继续他在物理学和医学成像相关工程方面的教育，并继续获得作为放射科医生的临床专业知识。在五年的资助期内，Morrell博士将应用他博士学位的多维激励技术。研究，以改善乳腺MRI和验证这些技术通过有限的临床试验。他将获得量子力学和其他物理学原理的直接相关的MRI与开发乳腺光谱成像的方法的目的更深入的了解。他将在临床试验的设计和研究的进行指导。拟议的研究计划的预期益处是提高乳腺癌的检测和减少良性乳腺病变的侵入性活检数量。基于该基金支持的试点研究，Morrell博士将通过R01或类似机制提交资金提案，以维持和扩大乳腺癌MRI的长期研究计划，与犹他州大学的肿瘤学，制药学和遗传学方面的成熟计划合作。