A pilot study of sodium breast MRI and relaxometry for characterization of breast cancer

钠乳腺 MRI 和松弛测量法表征乳腺癌的初步研究

• 批准号: 9982319
• 负责人: GLEN R MORRELL
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9982319
• 关键词: 3-Dimensional; Benign; Biological Markers; Biopsy; Breast; Breast Cancer Detection; Breast Cancer Risk Factor; Breast Magnetic Resonance Imaging; Breast biopsy; Cancer Detection; Clinical; Cone; Custom; Data; Detection; Diagnosis; Disease; Enrollment; Evaluation; Fatty acid glycerol esters; Funding; Future; Goals; Human; Hydrogen; Image; Investigation; Lesion; Literature; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammography; Measures; Methods; Motivation; Noise; Noninfiltrating Intraductal Carcinoma; Operative Surgical Procedures; Pathology; Patient Schedules; Patients; Phase; Physics; Physiologic pulse; Pilot Projects; Protocols documentation; Publishing; Radiation; Resolution; Roentgen Rays; Scanning; Schedule; Signal Transduction; Sodium; Specificity; Testing; Time; Tissues; Tumor Markers; Ultrasonography; Validation; Water; Woman; base; breast cancer diagnosis; breast lesion; cancer invasiveness; chemotherapy; clinically relevant; diagnostic accuracy; disease heterogeneity; disease natural history; imaging biomarker; improved; malignant breast neoplasm; molecular marker; quantitative imaging; screening; technology development; tumor

Abstract: This proposal evaluates sodium MRI and sodium relaxometry as markers of tumor invasiveness and grade of human breast cancer in a pilot study. Concentration of sodium in tissue may be a valuable molecular marker of malignancy. Previous studies have shown elevated sodium levels in large breast cancers. Sodium relaxometry parameters T1 and biexponential T2* have also been shown to be associated with malignancy but have not yet been systematically investigated in breast cancer. Our proposal includes two specific aims: 1) to develop and implement optimized sodium breast MRI hardware and protocols to maximize the accuracy of sodium concentration estimation and relaxometry, and 2) to conduct a pilot study of quantitative sodium MRI in patients scheduled for biopsy of suspicious lesions found by x-ray mammograms, ultrasound, or conventional MRI. This study will explore whether sodium levels and relaxometry data can discriminate between benign and malignant lesions. Data from this pilot study will provide preliminary data for a future proposal for more extensive large scale evaluation of sodium MRI for breast cancer. Our long-term motivation is to improve the specificity of breast MRI for detection of breast cancer. If the specificity of breast MRI can be increased through the use of sodium imaging, this will decrease the number of unnecessary breast biopsies and will provide more accurate information about extent of disease in patients with a new diagnosis of breast cancer to aid in the choice of appropriate therapy. The proposed technology development and pilot study are important steps toward this ultimate goal.

摘要： 这项建议评估钠核磁共振和钠松弛计量术作为肿瘤侵袭性和分级的标志物。 一项初步研究中的人类乳腺癌。 组织中钠浓度可能是判断肿瘤恶性程度的有价值的分子标志物。之前的研究已经 结果显示，大型乳腺癌患者的钠水平升高。钠弛豫参数T1和双指数 T2*也被证明与恶性肿瘤有关，但尚未进行系统研究 在乳腺癌方面。 我们的建议包括两个具体目标：1)开发和实施优化的钠乳腺MRI硬件 和协议，以最大限度地提高钠浓度估计和松弛测量的准确性，以及2)进行 定量钠核磁共振在X光可疑病变活检患者中的初步研究 乳房X光检查、超声波或常规核磁共振检查。这项研究将探索钠水平和 松弛测量数据可以区分良性和恶性病变。这项试点研究的数据将 为未来更广泛的大规模评估钠核磁共振成像的建议提供初步数据 乳腺癌。 我们的长期动机是提高乳腺MRI检测乳腺癌的特异性。如果 通过使用钠成像可以提高乳腺MRI的特异性，这将减少 不必要的乳房活组织检查，将提供更准确的患者疾病程度信息 有了新的乳腺癌诊断，有助于选择合适的治疗方法。建议的技术 开发和试点研究是迈向这一最终目标的重要步骤。