fMRI Assessment of Organophosphate Neurotoxicity

有机磷神经毒性的功能磁共振成像评估

• 批准号: 6991212
• 负责人: STEVEN B BIRD
• 金额: $ 12.51万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-09 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6991212
• 关键词: anticholinergic agent; bioimaging /biomedical imaging; bioterrorism /chemical warfare; central nervous system; cerebral ventricles; chlorohydrocarbon insecticide; environmental toxicology; functional magnetic resonance imaging; insecticide biological effect; laboratory rat; neurotoxicology; organophosphorus insecticide; peripheral nervous system; phrenic nerve; poisoning; respiratory center dysfunction; vagotomy

DESCRIPTION (provided by applicant) This application contains a four-year research training program for the development of an academic career in physiology and medicine. The candidate completed an emergency medicine residency at the University of Massachusetts Medical School in 2002 and has continued to perform research, teaching and clinical duties at the university. The described training program is designed to provide the candidate with the didactic and practical experience necessary for him to become an independent investigator in the field of organophosphate physiology. The scientific aims of this investigation focus on characterizing the central nervous system physiologic effects of organophosphorus compounds. The candidate has chosen Dr. Craig F. Ferris Ph.D. as a mentor for this project. As Director of the Center for Comparative Neuro-lmaging at the university, Dr. Ferris has extensive experience in CNS physiology and functional magnetic resonance imaging (fMRI). To further augment his training, the candidate will meet regularly with a respiratory neurologist and a biophysicist at his institution. The candidate's research efforts will focus on determining the mechanism by which organophosphorus agents exert their effects on respiration. Specific emphasis will be placed on determining: 1) the respiratory centers' response to organophosphates via fMRI imaging, with and without antidotal treatment; 2) the role of cortical inputs in the respiratory depression; and 3) the role of peripheral signals in modulating respiration. The combined Departments of Physiology and Emergency Medicine at the University of Massachusetts Medical School are an ideal setting for this grant and will provide Dr. Bird with the facilities, equipment and expertise necessary to achieve the goals set forth in this proposal.

描述（由申请人提供） 该应用程序包含一个为期四年的研究培训计划，用于发展生理学和医学的学术生涯。 该候选人于2002年在马萨诸塞州大学医学院完成了急诊医学住院医师培训，并继续在该大学从事研究、教学和临床工作。 所描述的培训计划旨在为候选人提供必要的教学和实践经验，使其成为有机磷酸盐生理学领域的独立调查员。 本研究的科学目的集中在表征有机磷化合物的中枢神经系统生理效应。 候选人选择了克雷格F医生。Ferris博士作为这个项目的导师 作为该大学比较神经成像中心的主任，Ferris博士在CNS生理学和功能磁共振成像（fMRI）方面拥有丰富的经验。 为了进一步加强培训，候选人将定期与所在机构的呼吸神经科医生和生物药理学家会面。 候选人的研究工作将侧重于确定有机磷制剂对呼吸作用的机制。 具体的重点将放在确定：1）呼吸中心的反应，有机磷通过功能磁共振成像，有和没有解毒剂治疗; 2）皮质输入的作用，呼吸抑制;和3）外周信号的作用，调节呼吸。 马萨诸塞州医学院的生理学和急诊医学的合并部门是该补助金的理想设置，并将为Bird博士提供必要的设施，设备和专业知识，以实现本提案中提出的目标。