USE OF AN ORGANOPHOSPHORUS (OP) HYDROLASE FOR ACUTE OP TOXICITY

使用有机磷 (OP) 水解酶治疗急性 OP 毒性

• 批准号: 8357959
• 负责人: STEVEN B BIRD
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357959
• 关键词: Acute; Dichlorvos; Enzymes; Funding; Grant; Human Development; Modeling; National Center for Research Resources; New England; Pesticides; Poisoning; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Toxic effect; United States National Institutes of Health; aryldialkylphosphatase; base; cost; improved; novel; safety testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this grant is and to test the safety and efficacy of a novel organophosphorus pesticide degrading enzyme, OpdA, in an NHP model. Proof that the enzyme is safe and effective against dichlorvos should provide the necessary impetus for further development for human use. Our central hypothesis is that OpdA is safe and improves survival after poisoning with dichlorvos.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该基金的目的是在NHP模型中测试新型有机磷农药降解酶OpdA的安全性和有效性。证明这种酶对敌敌畏是安全有效的，应该为进一步开发人类使用提供必要的动力。我们的中心假设是，OpdA是安全的，可以提高敌敌畏中毒后的存活率。