USE OF AN ORGANOPHOSPHORUS (OP) HYDROLASE FOR ACUTE OP TOXICITY

使用有机磷 (OP) 水解酶治疗急性 OP 毒性

• 批准号: 7958389
• 负责人: STEVEN B BIRD
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958389
• 关键词: Acute; Computer Retrieval of Information on Scientific Projects Database; Enzymes; Funding; Grant; Human Development; Hydrolase; Institution; Modeling; New England; Parathion; Pesticides; Poisoning; Primates; Research; Research Personnel; Resources; Source; Toxic effect; United States National Institutes of Health; base; improved; novel; safety testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purposes of this grant is and to test the safety and efficacy of a novel organophosphorus pesticide degrading enzyme, OpdA, in this NHP model. Proof that the enzyme is safe and effective against parathion should provide the necessary impetus for further development for human use. Our central hypothesis is that OpdA is safe and improves survival after poisoning with parathion.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 本基金的目的是测试新型有机磷农药降解酶OpdA在NHP模型中的安全性和有效性。证明这种酶对草甘膦是安全有效的，应该为人类使用的进一步发展提供必要的动力。我们的中心假设是，OpdA是安全的，并提高了中毒后的生存率。