Imaging and the Aging Brain

描述（由申请人提供）：纽约科学院与美国老龄化研究联合会计划于2006年5月16日和17日在纽约市举行一次为期两天的题为“成像和老龄化大脑”的会议。65岁或以上的美国老年人目前超过3590万，预计到2030年将达到7150万，使这部分美国人口占总人口的20%。这些人口统计数据揭示了对与衰老过程相关的疾病进行更深入研究以及更好地了解规范衰老过程的需求增加。脑功能和解剖结构发生了与脑损伤相关的变化。其中一些改变是正常衰老过程的一部分，而其他变化与病理变化有关，最终导致疾病，如阿尔茨海默病（AD），帕金森病（PD），中风，痴呆和轻度认知障碍（MCI）。重要的相关问题是什么发生在分子，细胞和系统范围内的水平？与疾病相关的调节相比，这在正常老化中有何不同？会议将汇集成像科学家，研究大脑老化的人，工业专家和临床医生，共同探索最新的方法及其在大脑生理学，行为和年龄相关疾病中的应用。神经影像学的进展为年龄相关疾病的病因学提供了新的见解，并为观察正常老化对大脑的影响提供了机会。本次研讨会预计将汇集多达200名科学界的领导人，探讨新技术，从最近的神经影像学倡议和转化研究应用的数据。为期2天的会议将交错的大脑和神经成像沿着从分子，细胞，系统，动物模型和人类受试者和患者的逐步演变的多种形式。会议分为4个主题，涵盖衰老和脑成像交叉的关键领域：1。分子的体内成像，2.整个生命周期的细胞和网络;3。衰老的影像学和生理学; 4.翻译应用; 5。和技术处于成像的最前沿。

DESCRIPTION (provided by applicant): The New York Academy of Sciences with the American Federation of Aging Research is planning a 2-day conference entitled/Imaging and the Aging Brain" to be held May 16th and 17th, 2006 in New York City. The number of older Americans, age 65 or greater is currently over 35.9 million, and is expected to reach 71.5 million by 2030, making this segment of the US population 20% of the total. These demographics bring to light the increased need for more intensive studies of diseases related to the aging process as well as a better understanding of the normative aging process. Age-related changes occur in brain function and anatomy. Some of these alterations are part of the normal aging process while other changes are associated with pathologic changes, ultimately resulting in diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke, dementia, and mild cognitive impairment (MCI). Important related questions are what occur at the molecular, cellular and system wide levels? And, how does this differ in normative aging as compared with disease-associated modulation? The meeting will bring together imaging scientists, those studying the aging brain, industrial experts and clinicians to jointly explore the most current methodologies and their application to brain physiology, behavior and age-related diseases. Advances in neuroimaging are providing new insights into the etiology of age-related diseases, as well as an opportunity to view the effects of normative aging on the brain. This symposium is expected to bring together as many as 200 leaders in the scientific community to explore new technologies, data from recent neuroimaging initiatives and translational research applications. The 2-day meeting will interleave the multiple modalities of brain and neuroimaging along with a progressive evolution from molecules, cells, systems, animal models and human subjects and patients. The conference is organized into 4 main themes encompassing key areas at the intersection of aging and brain imaging:1. In vivo imaging of molecules,2. Cells and networks throughout the lifespan;3. Imaging and physiology of aging; 4. Translational applications; 5. and Technologies at the forefront of imaging.