CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN NORMAL AGING

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。几个观察结果有助于推测脑葡萄糖代谢改变阿尔茨海默病（AD）。其中一个促成因素似乎是AD受试者中葡萄糖转运系统的缺陷。这项研究将验证海马结构葡萄糖缺陷标志着区域脆弱性的最早特征的理论。这将通过在轻度高血糖激发后通过正电子发射断层扫描观察葡萄糖活性来完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several observations have contributed to speculation that brain glucose metabolism is altered in Alzheimer's disease (AD). One of the contributing factors appears to be a defect in the glucose transport system in AD subjects. This study will test the theory that defects in hippocampal formation glucose mark the earliest features of regional vulnerability. This will be done by observing glucose activity via Positron Emission Tomography after a mild hyperglycemic challenge.