BIOMARKERS IN EARLY ALZHEIMER'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 开发一种针对阿尔茨海默病(AD)的非侵入性检测方法是非常可取的。本研究的目的是使用MRI和脑脊液生物标志物来确定在正常受试者中最早临床检测到的AD的变化。假设脑脊液P-tau水平将提高MRI测量萎缩的准确性，并将脑脊液淀粉样β蛋白测量作为认知障碍下降的预测指标。这项研究的基础是观察到，在一些正常和认知功能轻微受损的人中，内嗅皮层的神经元和体积损失与神经原纤维缠绕有关。影像研究缺乏特异性，但研究人员认为，与缠结相关的异常tau蛋白(P-tau 231)在认知功能轻度受损的人的脑脊液中升高，预测衰退，并且是AD特有的。这是一项历时3年的MRI和脑脊液纵向研究，研究对象为80名老年正常受试者(50名有记忆障碍)，这些受试者已经参加了另一项研究。将进行核磁共振检查以测量海马体的大小。将进行腰椎穿刺术，以测量tau和淀粉样β蛋白。标准化的神经心理学数据也将被收集。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It would be highly desirable to develop a non-invasive test for Alzheimer's disease (AD). The aim of this study is to use MRI and CSF biomarkers to identify in normal subjects the earliest clinically detected changes of AD. The hypothesis is that CSF P-tau levels will improve accuracy of MRI measurements of atrophy and CSF amyloid-beta measurements as a predictor of decline to cognitive impairment. The study is based on the observation that in some normal and minimally cognitively impaired individuals, neuronal and volume loss in the entorhinal cortex can be seen in association with neurofibrillary tangles. Imaging studies lack specificity, but the investigators suggest that tangle-related abnormal tau proteins (P-tau 231) are elevated in the CSF of minimally cognitively impaired individuals, predicting decline, and are specific for AD. This is a longitudinal MRI and CSF study over 3 years (3 evaluations) on 80 elderly normal subjects (50 with memory complaints) already enrolled in another study. MRI will be performed to measure hippocampus size. Lumbar puncture will be done to measure tau and amyloid-beta proteins. Standardized neuropsychological data will also be collected.