Automating Patient-Specific Model Development

自动化患者特定模型开发

• 批准号: 7124703
• 负责人: NICOLE M GROSLAND
• 金额: $ 14.4万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-21 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124703
• 关键词: bioimaging /biomedical imaging; biomechanics; biomedical automation; computer program /software; computer system design /evaluation; human tissue; image enhancement; image guided surgery /therapy; mathematical model; model design /development; musculoskeletal imaging /visualization /scanning; skeletal stress; skeletal system; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Musculoskeletal finite element (FE) analysis is an invaluable tool in orthopaedic-related research. While it has provided significant biomechanical insight, the demands associated with modeling the geometrically complex structures of the human body often limit its utility. The often prohibitive amount of model development time is further compounded by the time required to process medical image datasets to identify the distinct anatomical structures of interest. Yet this process is a necessary preprocessing step for model development. As a result, most of the analyses reported in the literature refer to 'average' bone geometry. The broad objective of our research plan is to develop a robust software package (IA-FEMESH) to automate the development of patient-specific finite element (FE) models. In pursuit of this objective we propose to merge unique technologies to automate image dataset segmentation; material property extraction and assignment; and direct FE model development (automated meshing). While direct scanning of the bones of interest will be used to validate the automated image segmentation routines, experimental cadaveric contact stress measurements will provide a standard against which to validate the FE contact formulations. Furthermore, the FE models generated by our software package will be compared to models of the same bone(s) created via a commercial pre-processing package. While the hand/wrist represents the primary structures of interest proposed in this application, the tools will be generalized to be used in many orthopaedic applications. In addition to establishing the aforementioned software package, the proposed project will ultimately yield specimen specific FE models of the various joints of the upper extremity, namely the hand. Such models will position us to provide information about the load transfer, characteristics of the normal joints and in the future to demonstrate, for example, the effects of ligamentous instabilities, posttraumatic malalignments, fractures, and various surgical procedures.

描述（由申请人提供）：肌肉骨骼有限元（FE）分析是骨科相关研究中的宝贵工具。虽然它提供了重要的生物力学见解，但与人体几何复杂结构建模相关的需求往往限制了其实用性。处理医学图像数据集以识别感兴趣的不同解剖结构所需的时间进一步增加了通常令人望而却步的模型开发时间。然而，这个过程是模型开发的必要预处理步骤。因此，文献中报告的大多数分析均涉及“平均”骨几何结构。 我们的研究计划的主要目标是开发一个强大的软件包（IA-FEMESH），以自动开发患者特定的有限元（FE）模型。为了实现这一目标，我们建议合并独特的技术来自动化图像数据集分割;材料属性提取和分配;以及直接FE模型开发（自动网格化）。虽然感兴趣骨骼的直接扫描将用于验证自动图像分割程序，但实验尸体接触应力测量将提供验证FE接触公式的标准。此外，我们的软件包生成的FE模型将与通过商业预处理包创建的相同骨的模型进行比较。虽然手/腕代表了本申请中提出的主要感兴趣结构，但这些工具将被推广用于许多整形外科应用。除了建立上述软件包，拟议的项目将最终产生标本特定的有限元模型的各种关节的上肢，即手。 这些模型将使我们能够提供有关负荷转移的信息，正常关节的特征，并在未来证明，例如，韧带不稳定，创伤后排列不良，骨折和各种外科手术的影响。

项目成果

Semi-automated phalanx bone segmentation using the expectation maximization algorithm.

• DOI: 10.1007/s10278-008-9151-y
• 发表时间: 2009-10
• 期刊: JOURNAL OF DIGITAL IMAGING
• 影响因子: 4.4
• 作者: Ramme, Austin J.;DeVries, Nicole;Kallemyn, Nicole A.;Magnotta, Vincent A.;Grosland, Nicole M.
• 通讯作者: Grosland, Nicole M.

Comparison of Displacement-Based and Force-Based Mapped Meshing.

基于位移和基于力的映射网格划分的比较。

• 发表时间: 2008
• 期刊: MIDAS journal
• 作者: Magnotta,VincentA;Li,Wen;Grosland,NicoleM
• 通讯作者: Grosland,NicoleM

IA-FEMesh: an open-source, interactive, multiblock approach to anatomic finite element model development.

• DOI: 10.1016/j.cmpb.2008.12.003
• 发表时间: 2009-04
• 期刊: Computer methods and programs in biomedicine
• 影响因子: 6.1
• 作者: Grosland NM;Shivanna KH;Magnotta VA;Kallemeyn NA;DeVries NA;Tadepalli SC;Lisle C
• 通讯作者: Lisle C

Ia-FEMesh: anatomic FE models--a check of mesh accuracy and validity.

Ia-FEMesh：解剖有限元模型——网格精度和有效性的检查。

• 发表时间: 2009
• 期刊: The Iowa orthopaedic journal
• 作者: Devries,NicoleA;Shivanna,KiranH;Tadepalli,SrinivasC;Magnotta,VincentA;Grosland,NicoleM
• 通讯作者: Grosland,NicoleM