Electronically Reconfigurable Microfabricated Tetrodes

电子可重构微制造四极管

• 批准号: 7106462
• 负责人: Babak Ziaie
• 金额: $ 14.49万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-03 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106462
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain electrical activity; hippocampus; implant; laboratory rat; medical implant science; microelectrodes

DESCRIPTION (provided by applicant): This proposal seeks funding (R21) under the "Neurotechnology Research, Development, and Enhancement" program to develop an electronically reconfigurable microfabricated tetrode array. Under the proposed research, we will design, fabricate, and test a 3D microfabricated electronically reconfigurable tetrode with multiplexing capability for multi-neuronal recording. Each tetrode will consist of four silicon shanks each having eight recording sites. A three transistor analog multiplexer located next to each site allows each one to be individually selected thus reducing the number of leads (to four for an eight channel electrode). This will make possible the eventual creation of electrodes with hundreds of recording sites. We will start with an eight channel electrode as a proof-of-concept. The four shanks are attached to a silicon backend containing the bonding pads through foldable polyimide links. The connecting polyimide links are only partially cured during the fabrication process and their complete curing following the release results in automatic folding into the desired shape. A silicon platform is fabricated to house 16 tetrode assembly resulting in a total of 64 simultaneous recording at any moment. The fabrication process uses a silicon-on-insulator substrate. The active tetrode will be tested in vivo in hippocampal recordings from awake, behaving rats. Hippocampal place cells are well-understood and have been extensively tested with tetrode. This makes them well-suited to testing new technology. Hippocampus has a very well-understood anatomical structure which will allow quantification of the recording location of each site. This makes it an ideal structure with which to test new recording technology.

描述（由申请人提供）：该提案寻求“神经技术研究，开发和增强”计划下的资金（R21），以开发电子可重新配置的微制造四极阵列。根据所提出的研究，我们将设计，制造和测试一个3D微电子可重构四极多路复用能力的多神经元记录。每个四极管由四个硅柄组成，每个硅柄有八个记录点。位于每个位置旁边的三晶体管模拟多路复用器允许单独选择每一个，从而减少引线数量（对于八通道电极为四个）。这将使最终创建具有数百个记录位点的电极成为可能。我们将从八通道电极开始，作为概念验证。四个柄部通过可折叠的聚酰亚胺链接连接到包含键合焊盘的硅后端。在制造过程中，连接的聚酰亚胺链接仅部分固化，并且在释放之后它们的完全固化导致自动折叠成所需形状。一个硅平台被制造成容纳16个四极管组件，从而在任何时刻都能同时记录64个。制造过程使用绝缘体上硅衬底。将在清醒的行为大鼠的海马记录中对活性四极管进行体内测试。海马位置细胞是很好理解的，并已广泛测试与tetrode。这使得他们非常适合测试新技术。海马具有非常好理解的解剖结构，这将允许量化每个部位的记录位置。这使其成为测试新记录技术的理想结构。