Integrated Wireless Tracking and Dosimetry for Radiation Oncology

用于放射肿瘤学的集成无线跟踪和剂量测定

• 批准号: 7387816
• 负责人: Babak Ziaie
• 金额: $ 19.79万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-12 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7387816
• 关键词: Abdomen; Address; Algorithms; Area; Caliber; Calibration; Catheters; Charge; Chest; Clinical; Collaborations; Computers; Coupled; Detection; Development; Devices; Dimensions; Dose; Electric Capacitance; Engineering; Exposure to; Frequencies; Funding; Glass; Grant; Hafnium; Immobilization; Implant; In Situ; Ionizing radiation; Lasers; Link; Location; Magnetism; Malignant neoplasm of prostate; Measurement; Measures; Metals; Methods; Microfabrication; Monitor; Motion; Nanotechnology; Noise; Oxides; Performance; Phase; Physics; Placement; Radiation; Radiation Oncology; Radiation therapy; Radiometry; Range; Rectum; Research; Research Project Grants; Resolution; Scheme; Schools; Score; Shapes; Signal Transduction; Silicon; Structure; Supervision; Telemetry; Testing; Thick; Time; Tissues; Tube; Tumor Tissue; Universities; Urethra; Wireless Technology; base; cancer therapy; capsule; design; dosage; dosimetry; hypodermic needle; improved; in vivo; instrumentation; magnetic field; nanoscale; novel; programs; response; seal; sensor; tool; tumor

DESCRIPTION (provided by applicant): This proposal seeks funding for an R21 grant under the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. This microdevice will be an invaluable tool in radiation oncology for real-time received dosage measurements and tumor motion management. The primary envisioned application of the proposed device is for (1) Stereotactic Body Radiation Therapy (SBRT) treatments of thoracic and abdominal tumors and for (2) High Dose Radiation (HDR) treatment of prostate cancer. For SBRT applications transponders will be implanted in the tumor tissue and its vicinity for effective monitoring of dose delivery and tissue tracking at treatment. For HDR prostate cancer treatment the proficient application of the device would require its placement in the catheter passing through urethra to monitor dose along the radiosensitive membranous tube during implant or in the catheter attached to the balloon placed inside the rectum (balloon being utilized for better immobilization of the target and more favorable dose distribution in the rectum wall). For the radiation dose measurement, we will explore a device structure and detection scheme based on the depletion capacitance change associated with radiation-generated negative charge in the hafnium oxide gate of a metal-on-insulator (MOS) structure. In order to monitor tumor location in real-time, we will use a magnetic tracking method with superior signal- to-noise performance and enhanced interrogation range. Both of these devices will be integrated on the same silicon substrate and receive power from an inductively coupled link (no battery required), hence simplifying the packaging and encapsulation. Integrated Wireless Tracking and Dosimetry for Radiation Oncology This is a revised R21 application submitted in response to the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. Although the reviews were positive (score 225), several concerns were raised by the panel which we have addressed in the present re-submission. The paragraphs that we have added or changed in response to the review use a different font (Palatino Linotype).

描述（由申请人提供）：该提案寻求 NIH/NIBIB 探索/发展研究资助计划下的 R21 资助，以开发一种用于无线肿瘤跟踪和原位辐射剂量测定的新型集成微转发器。该微型设备将成为放射肿瘤学中实时接收剂量测量和肿瘤运动管理的宝贵工具。该设备的主要设想应用是（1）胸部和腹部肿瘤的立体定向放射治疗（SBRT）和（2）前列腺癌的高剂量放射（HDR）治疗。对于 SBRT 应用，应答器将被植入肿瘤组织及其附近，以有效监测治疗时的剂量输送和组织跟踪。对于 HDR 前列腺癌治疗，该装置的熟练应用需要将其放置在穿过尿道的导管中，以在植入期间监测沿放射敏感膜管的剂量，或放置在连接到放置在直肠内的气球上的导管中（气球用于更好地固定目标并在直肠壁中实现更有利的剂量分布）。对于辐射剂量测量，我们将探索一种基于与绝缘体上金属 (MOS) 结构的氧化铪栅极中辐射产生的负电荷相关的耗尽电容变化的器件结构和检测方案。为了实时监测肿瘤位置，我们将使用具有优越信噪比性能和增强询问范围的磁跟踪方法。这两种器件都将集成在同一硅基板上，并从电感耦合链路接收电力（无需电池），从而简化了封装和封装。用于放射肿瘤学的集成无线跟踪和剂量测定 这是为响应 NIH/NIBIB 探索性/发展研究资助计划而提交的修订版 R21 申请，旨在开发一种用于无线肿瘤跟踪和原位辐射剂量测定的新型集成微转发器。尽管评论是积极的（得分 225），但专家组提出了一些担忧，我们已在当前重新提交的材料中解决了这些问题。我们根据审查添加或更改的段落使用不同的字体（Palatino Linotype）。