An implantable sensor for wireless measurement of interstitial pressure

用于无线测量间质压力的植入式传感器

• 批准号: 8244038
• 负责人: Babak Ziaie
• 金额: $ 23.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-15 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8244038
• 关键词: Animal Testing; Blood flow; Caliber; Calibration; Clinical; Collaborations; Computers; Data; Devices; Dose; Drug Delivery Systems; Engineering; Frequencies; Funding; Glass; Goals; Human; Hypoxia; Implant; In Vitro; Indiana; Intercellular Fluid; Length; Light; Measurement; Measures; Microfabrication; Monitor; Nanotechnology; Outcome; Oxygen; Partial Pressure; Performance; Pharmaceutical Preparations; Principal Investigator; Radiation; Radiation Oncology; Radiation therapy; Rattus; Research; Resolution; Schools; Side; Solid Neoplasm; Subcutaneous Tissue; Testing; Therapeutic; Therapeutic Agents; Tissues; Tube; Universities; Wireless Technology; Xenograft Model; bevacizumab; capsule; chemotherapeutic agent; chemotherapy; design; implantation; in vivo; interstitial; medical schools; multidisciplinary; oncology; pressure; programs; sensor; tumor

DESCRIPTION (provided by applicant): The goal of this project is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. IFP is an important clinical parameter indicating the accessibility of many solid tumors to therapeutic agents. This is in light of the fact that higher levels of IFP in tumors impede the efficient delivery of drugs. In addition to chemotherapy, radiation therapy can also benefit from lowering the IFP by increasing the oxygen partial pressure in hypoxic tumor regions. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents used to lower the IFP. In addition, by measuring the IFP, one can tailor the administration of IFP lowering drugs to optimize their efficacy (e.g., administration of the chemotherapeutic agent when the IFP is reduced). During the course of the proposed research we will develop a micro-transponder for wireless measurement of IFP inside solid tumors. The micro-device consists of a capacitive pressure sensor with an integrated Guyton capsule connected to an inductor, thus forming a parallel LC circuit whose resonant frequency is a measure of interstitial pressure. The LC resonator is packaged inside a glass tube (1.5mm in diameter and 1cm in length) with the Guyton capsule side exposed to the tissue. The presence of Guyton capsule allows accurate measurements of IFP following the implantation since interstitial fluid can easily ingress into the device. PUBLIC HEALTH RELEVANCE: The objective of this proposal is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. High levels of IFP impede the effective delivery of drugs to many tumors. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents and tailoring the administration of IFP lowering drugs to optimize their efficacy.

描述（由申请人提供）：本项目的目标是开发一种用于测量实体瘤间质液压力（IFP）的植入式微型应答器。IFP是指示许多实体瘤对治疗剂的可及性的重要临床参数。这是鉴于肿瘤中较高水平的IFP阻碍了药物的有效递送。除了化疗，放射治疗也可以通过增加缺氧肿瘤区域的氧分压来降低IFP。使用植入式微应答器测量IFP的能力将为评估用于降低IFP的各种药理学试剂提供有价值的数据。此外，通过测量IFP，可以定制IFP降低药物的施用以优化其功效（例如，当IFP降低时，给予化疗剂）。在拟议的研究过程中，我们将开发一个微型转发器，用于实体肿瘤内IFP的无线测量。该微型装置由一个电容式压力传感器与集成的盖顿胶囊连接到一个电感器，从而形成一个并联的LC电路，其谐振频率是一个衡量的间隙压力。LC谐振器封装在玻璃管（直径1.5 mm，长度1 cm）内，盖顿囊侧暴露于组织。盖顿囊的存在允许在植入后准确测量IFP，因为组织液可以容易地进入器械。 公共卫生相关性：本提案的目的是开发一种用于测量实体瘤间质液压力（IFP）的植入式微型应答器。高水平的IFP阻碍了药物向许多肿瘤的有效递送。使用可植入微应答器测量IFP的能力将为评估各种药理学试剂和定制降低IFP的药物的施用以优化其功效提供有价值的数据。