Depression in Children and Adolescents with Type 1 Diabetes

描述(由申请人提供)： 这项K23指导的以患者为导向的研究职业发展奖的候选人是一名即将晋升到初级教员职位的研究员。候选人的长期目标是在儿科糖尿病方面从事学术研究，开发和加强有效的、有经验支持的方法，以改善儿童、青少年及其家庭的健康结果和生活质量。该奖项要实现的具体短期职业目标包括：1)培养研究方法方面的专门知识，以更好地了解青年及其家庭的情绪功能对1型糖尿病相关管理和健康结果的影响；2)侧重于1型糖尿病青年中的抑郁，并确定预测青年1型糖尿病中抑郁的因素；3)描述干预和/或预防的可改变因素，以便准备R01应用，重点是干预和预防儿童和青少年1型糖尿病中的抑郁。为了实现这些目标，候选人提出了一项为期五年的培训计划。候选人的主要导师在儿科学和流行病学方面有很强的背景，这构成了她在维护儿童、青少年和患有糖尿病的年轻人的健康和维持正常生长、发育和家庭功能方面的研究和临床兴趣的基础。导师团队包括在行为、生物学和流行病学领域拥有与儿童糖尿病相关的专业知识的教职员工。培训活动包括高级研究方法的课程作业，导师的教学指导，以及参加研究研讨会。该奖项的拟议研究计划包括两项研究。研究1是对患有1型糖尿病的青少年抑郁症的评估方法的检验。此外，通过诊断性访谈，研究1将记录患有1型糖尿病的儿童和青少年的大样本中抑郁的患病率，并记录与抑郁相关的因素。研究2是对这些年轻人的抑郁、坚持与血糖和健康结果之间的联系的纵向检查。采用中介分析的潜在生长模型将提供有价值的数据，说明青少年1型糖尿病患者的抑郁、依从性和血糖结果之间的联系。这项研究的发现有可能影响患有1型糖尿病的儿童和青少年及其家庭的健康和生活质量。

DESCRIPTION (provided by applicant): The candidate for this K23 Mentored Patient-Oriented Research Career Development Award is a research fellow advancing to a junior faculty position. The candidate's long-term goal is to have an academic research career in pediatric diabetes to develop and enhance effective, empirically-supported methods for improving health outcomes and quality of life for children, adolescents, and their families. Specific short-term career goals to be achieved with this award include: 1) to develop an expertise in research methodologies to better understand the impact of emotional functioning of youth and their families on the management and health outcomes associated with type 1 diabetes, 2) to focus on depression in youth with type 1 diabetes and identify the factors predictive of depression in youth with type 1 diabetes, 3) to delineate modifiable factors for intervention and / or prevention in order to prepare an R01 application with a focus on intervention and prevention of depression in children and adolescents with type 1 diabetes. To achieve these goals, the candidate proposes a five-year training program. The candidate's primary mentor has a strong background in pediatrics and epidemiology that forms the basis for her research and clinical interests in preserving the health, and sustaining normal growth, development, and family functioning for children, adolescents, and young adults with diabetes. The mentorship team includes faculty members with expertise in behavioral, biologic, and epidemiologic areas as they relate to pediatric diabetes. Training activities include coursework in advanced research methodology, didactic instruction from mentors, and participation in research seminars. The proposed research plan for this award includes two studies. Study 1 is an examination of methods for assessing depression in youth with type 1 diabetes. Further, through a diagnostic interview, Study 1 will document the prevalence of depression in a large sample of children and adolescents with type 1 diabetes and document factors associated with depression. Study 2 is a longitudinal examination of the links between depression, adherence, and glycemic and health outcomes of these youth. Latent growth modeling with mediational analyses will provide valuable data on the links between depression, adherence, and glycemic outcomes in youth with type 1 diabetes. Findings from this research have the potential to impact the health and quality of life of children and adolescents with type 1 diabetes and their families.