Psychobiological Reactivity in Sickle Cell Disease

镰状细胞病的心理生物学反应

• 批准号: 7123459
• 负责人: Marsha J Treadwell
• 金额: $ 14.95万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123459
• 关键词: autonomic nervous system; child psychology; clinical research; human subject; middle childhood (6-11); pain; patient oriented research; physiology; psychobiology; sickle cell anemia

DESCRIPTION (provided by applicant): This application describes a five-year plan of training and development for the candidate who will refocus her clinical psychology career from service and program administration to patient-oriented bio-behavioral research in sickle cell disease. This transition will occur under the primary mentorship of Dr. Tom Boyce, a highly-regarded expert in psychobiological reactivity and health outcomes. Dr. Lori Styles, an accomplished basic and clinical researcher in sickle cell disease, will serve as co-mentor. Both sponsors have mentored a number of scientists who have gone on to independent careers in biomedical research. The training program will integrate resources from the University of California-Berkeley and Children's Hospital and Research Center at Oakland, as well as diverse concepts and methods from the fields of medicine and psychology. The candidate's collaborators will supplement her training by lending their expertise in autonomic reactivity, biomedical science and psychiatry. An advisory committee of clinical scientists with distinguished contributions to psychological and medical research in sickle cell disease will provide guidance to the candidate as she broadens her focus to an academic research career. The research plan will focus on psychobiological reactivity in response to laboratory challenge, a novel individual difference variable that integrates physiological and psychological factors, for a cohort of pediatric patients with sickle cell disease. In our pilot study, a measure of autonomic reactivity was the only variable among those studied that bore a strong association with clinical disease severity for young children with sickle cell disease. The aims of the proposed research are to: (1) evaluate psycho-biological reactivity as a robust predictor of sickle pain, defined as rate of painful episodes and daily pain frequency and intensity, for children ages five to twelve with sickle cell disease; and (2) to evaluate the independent and combined influences of physiological and psychological factors on outcomes for children with sickle cell disease. This study will offer new insight into predictors of outcomes for SCD that can in turn inform the design of more effective interventions. The strengths of the institutions and the candidate combined will maximize the candidate's potential for the successful transition into a career as an independent biobehavioral scientist. (End of Abstract)

描述（由申请人提供）： 该申请描述了一个五年的培训和发展计划，为候选人谁将重新关注她的临床心理学职业生涯从服务和项目管理，以病人为导向的生物行为研究镰状细胞病。 这一过渡将在以下主要指导下进行： 博士汤姆博伊斯，一位在心理生物反应和健康结果方面备受尊敬的专家。 洛里斯泰尔斯博士，一个有成就的基础和临床研究镰状细胞病，将担任共同导师。 这两个赞助商都指导了一些科学家，他们已经在生物医学研究中独立工作。 该培训计划将整合加州大学伯克利分校和奥克兰儿童医院和研究中心的资源，以及医学和心理学领域的各种概念和方法。 候选人的合作者将通过提供他们在自主反应，生物医学科学和精神病学方面的专业知识来补充她的培训。 一个由对镰状细胞病的心理和医学研究有杰出贡献的临床科学家组成的咨询委员会将为候选人提供指导，因为她将重点扩大到学术研究事业。 该研究计划将重点关注镰状细胞病儿科患者队列对实验室挑战的心理生物学反应，这是一种整合生理和心理因素的新型个体差异变量。 在我们的初步研究中，自主神经反应性的测量是研究中唯一与镰状细胞病幼儿临床疾病严重程度密切相关的变量。 拟议研究的目的是：（1）评估心理-生物反应性作为镰状细胞病儿童5至12岁镰状细胞病疼痛的可靠预测因子，定义为疼痛发作率和每日疼痛频率和强度;（2）评估生理和心理因素对镰状细胞病儿童结局的独立和综合影响。 这项研究将为SCD的结局预测因素提供新的见解，从而为更有效的干预措施的设计提供信息。 机构和候选人的优势相结合，将最大限度地提高候选人的潜力，成功过渡到职业生涯作为一个独立的生物行为科学家。 (End摘要）