Psychobiological Reactivity in Sickle Cell Disease

描述(由申请人提供)： 这份申请描述了候选人的五年培训和发展计划，该计划将把她的临床心理学职业生涯的重点从服务和项目管理转向以患者为中心的镰状细胞疾病的生物行为研究。这一过渡将在以下主要指导下进行 汤姆·博伊斯博士，一位备受推崇的心理生物反应性和健康结果专家。Lori Styles博士是一位在镰状细胞疾病方面颇有成就的基础和临床研究人员，他将担任共同导师。这两家赞助商都指导了许多在生物医学研究领域独立发展的科学家。该培训项目将整合加州大学伯克利分校和奥克兰儿童医院和研究中心的资源，以及医学和心理学领域的不同概念和方法。这位候选人的合作者将通过提供自主反应、生物医学和精神病学方面的专业知识来补充她的培训。一个由在镰状细胞疾病的心理和医学研究方面做出杰出贡献的临床科学家组成的咨询委员会将为候选人提供指导，因为她正在将重点扩大到学术研究生涯。 该研究计划将重点放在应对实验室挑战的心理生物学反应上，实验室挑战是一种新的个体差异变量，整合了生理和心理因素，适用于一组患有镰状细胞疾病的儿科患者。在我们的初步研究中，自主神经反应性的测量是被研究的唯一变量，与患有镰状细胞病的幼儿的临床疾病严重程度有很强的相关性。拟议研究的目的是：(1)评估心理生物反应性作为镰刀痛的可靠预测因子，其定义为5至12岁患有镰状细胞病的儿童的疼痛发作比率以及日常疼痛频率和强度；以及(2)评估生理和心理因素对患有镰状细胞病的儿童预后的独立和联合影响。这项研究将为SCD预后的预测因素提供新的见解，进而为设计更有效的干预措施提供信息。这些机构和候选人的优势结合在一起，将最大限度地发挥候选人成功过渡到独立生物行为科学家职业的潜力。(摘要结束)

DESCRIPTION (provided by applicant): This application describes a five-year plan of training and development for the candidate who will refocus her clinical psychology career from service and program administration to patient-oriented bio-behavioral research in sickle cell disease. This transition will occur under the primary mentorship of Dr. Tom Boyce, a highly-regarded expert in psychobiological reactivity and health outcomes. Dr. Lori Styles, an accomplished basic and clinical researcher in sickle cell disease, will serve as co-mentor. Both sponsors have mentored a number of scientists who have gone on to independent careers in biomedical research. The training program will integrate resources from the University of California-Berkeley and Children's Hospital and Research Center at Oakland, as well as diverse concepts and methods from the fields of medicine and psychology. The candidate's collaborators will supplement her training by lending their expertise in autonomic reactivity, biomedical science and psychiatry. An advisory committee of clinical scientists with distinguished contributions to psychological and medical research in sickle cell disease will provide guidance to the candidate as she broadens her focus to an academic research career. The research plan will focus on psychobiological reactivity in response to laboratory challenge, a novel individual difference variable that integrates physiological and psychological factors, for a cohort of pediatric patients with sickle cell disease. In our pilot study, a measure of autonomic reactivity was the only variable among those studied that bore a strong association with clinical disease severity for young children with sickle cell disease. The aims of the proposed research are to: (1) evaluate psycho-biological reactivity as a robust predictor of sickle pain, defined as rate of painful episodes and daily pain frequency and intensity, for children ages five to twelve with sickle cell disease; and (2) to evaluate the independent and combined influences of physiological and psychological factors on outcomes for children with sickle cell disease. This study will offer new insight into predictors of outcomes for SCD that can in turn inform the design of more effective interventions. The strengths of the institutions and the candidate combined will maximize the candidate's potential for the successful transition into a career as an independent biobehavioral scientist. (End of Abstract)