Intramuscular Triglyceride in Impaired Glucose Tolerance

描述（由申请人提供）： 候选人：候选人Leigh Perreault，医学博士，是一名经过委员会认证的内科医生和内分泌学家，在过去十年中在流行病学，基础科学和临床研究方面拥有丰富的经验。她最近的工作研究性别差异胰岛素行动后，急性运动是由内分泌研究员基金会奖的支持。该项目产生了新的和重要的差异，奠定了基础，继续研究该地区的运动燃料代谢，因为它涉及到胰岛素的行动。毫无保留地，最突出的职业目标是候选人作为一名独立的物理学家和科学家取得卓越成就。指导病人为导向的研究职业发展奖将提供必要的培训，以追求和实现这一目标。 职业发展：培训计划包括两个主要要素：1）通过当地导师以及三个预定的学徒制获得令人印象深刻的新研究技能; 2）教育活动，包括正式的课堂工作，以及出席和参加全国会议，当地研讨会和期刊俱乐部，以及一对一的导师互动。 研究计划：该项目的总体目标是描述骨骼肌胰岛素抵抗发展的性别差异。了解这些差异将有助于扩大我们对胰岛素抵抗本身的病理生理学的了解，并有助于胰岛素增敏治疗的靶向。一般的假设是，男性和女性糖耐量受损（IGT）通过不同的机制在骨骼肌中产生胰岛素抵抗。具体来说，我们假设这是通过女性氧化能力降低和男性过氧化物酶体增殖物激活受体（PPAR）α（及其靶基因）作用降低而发生的。此外，女性的运动训练和男性的贝特类药物治疗将减轻这些紊乱。最先进的技术将会崩溃。环境：候选人的培训环境是特殊的。导师罗伯特·H·Eckel博士是胰岛素作用和底物摄取领域的国际专家，而且是一位经过验证的导师。共同导师，克里斯托弗A。DeSouza博士是学术研究领域的一颗冉冉升起的星星，在运动和底物使用方面具有专业知识。总的来说，导师、合作者和机构承诺都很出色。

DESCRIPTION (provided by applicant): Candidate: The candidate, Leigh Perreault, MD, is a board-certified internist and endocrinologist with experience in epidemiologic, basic science, and clinical research spanning the past decade. Her most recent work examining gender differences in insulin action following acute exercise was supported by an Award from the Endocrine Fellows Foundation. This project has yielded novel and important differences which have layed the foundation for continuing research in the area exercise fuel metabolism as it pertains to insulin action. Without reservation, the most outstanding career goal is for the candidate to achieve excellence as an independent physician-scientist. The Mentored Patient-Oriented Research Career Development Award would provide the necessary training to pursue and achieve this goal. Career Development: The training plan consists of two primary elements: 1) the acquistion of an impressive number of new research skills via the local mentors as well as three scheduled apprenticeships away; and 2) educational activities, including formal classroom work, as well as attendance and participation in national meetings, local seminars and journal clubs, and one-on-one mentor interactions. Research Plan: The overall aim of the proposed project is to delineate gender differences in the development of insulin resistance in skeletal muscle. Understanding such differences would help expand our knowledge of the pathophysiology of insulin resistance itself, as well as aid in the targeting of insulin sensitizing therapy. The general hypothesis is that men and women with impaired glucose tolerance (IGT) develop insulin resistance in skeletal muscle through different mechanisms. Specifically, we hypothesize that this occurs via decreased oxidative capacity in women, and decreased action of peroxisome proliferatoractivated receptor (PPAR) alpha (and its target genes) in men. Furthermore, exercise training in women, and fibrate therapy in men, will attenuate these derangements. State-of-the-art tecnhiques will be imployed. Environment: The environment for the candidate's training is exceptional. The mentor, Robert H. Eckel, MD, is an international expert in the area of insulin action and substrate uptake and, furthermore, is a proven mentor. The co-mentor, Christopher A. DeSouza, PhD, is a rising star in academic research with expertise in exercise and substrate use. Collectively, the mentors, collaborators, and institutional commitment excels.