INSULIN ACTION & SECRETION IN PRE-DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究旨在描述和比较糖尿病前期的三种表型与年龄、性别和体重指数匹配的正常葡萄糖耐量人群。 具体来说，空腹血糖受损（IFG）、糖耐量受损（IGT）和两者（IGT/IFG）的人将接受胰岛素分泌（通过葡萄糖逐步升高方案）和胰岛素作用（胰岛素钳夹+稳定同位素）的广泛测试，并与正常葡萄糖耐量（NGT）的人进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is aimed at characterizing and comparing the three phenotypes of pre-diabetes to age, sex, and body mass index-matched people with normal glucose tolerance. Specifically, people with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and both (IGT/IFG) will undergo extensive testing of their insulin secretion (via glucose step-up protocol) and insulin action (insulin clamp + stable isotopes) and compared to those with normal glucose tolerance (NGT).