Fatty Acid Concentrations and Myelin Integrity in Young People at Ultra-High Risk of Psychosis

多不饱和脂肪酸（PUFAs）在所有生物的许多生理过程中起着重要作用。髓鞘形成是指一种叫做髓磷脂的脂肪层在神经细胞周围积聚，使神经细胞能够更快地传递信息。PUFA对髓鞘形成至关重要，有证据表明，精神分裂症患者的PUFA浓度下降和脑白质（髓鞘）病理。这些异常背后的机制尚不清楚。

Polyunsaturated fatty acids (PUFAs) play an important role in many physiological processes in all organisms. Myelination is the process by which a fatty layer, called myelin, accumulates around nerve cells enabling nerve cells to transmit information faster. PUFAs are essential for myelination, and there is evidence documenting decreased PUFA concentrations and brain white matter (myelin) pathology in people with schizophrenia. The mechanisms underlying these abnormalities are not understood.