Genomic and Proteomic Network-Premature Birth Research

基因组和蛋白质组网络-早产研究

• 批准号: 6943201
• 负责人: MICHAEL W. VARNER
• 金额: $ 44.12万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943201
• 关键词: biomarker; biotechnology; blood tests; cervical /vaginal smear; clinical research; cooperative study; cytokine; early diagnosis; female reproductive system disorder diagnosis; functional /structural genomics; genetic markers; human genetic material tag; human subject; microarray technology; molecular biology information system; patient oriented research; premature infant human; premature labor; proteomics; women' s health

DESCRIPTION (provided by applicant): This proposal constitutes the University of Utah application for the NICHD Genomic and Proteomic Network for Premature Birth Research. The University of Utah has numerous unique strengths that make it an ideal center for the network. These include: I. Research Productivity in Multicenter Collaborative Studies: The University of Utah Maternal-Fetal Medicine (MFM) Division has made substantial contributions to over 15 multicenter clinical trials during the past five years and is a leading recruitment center for the NICHD/MFMU Network. Over 12,000 Utah patients were enrolled in the recently completed FASTER trial, accounting for almost 32% of subjects in the 12- center trial. The University of Utah also participates in the Stillbirth Collaborative Research Network and the Global Network for Women's and Children's Health Research. II. Premature Birth: The University of Utah enjoys international recognition as a center of excellence for clinical care and research on premature birth. III. Expertise in the Use of Genomic and Proteomic Techniques to Study Premature Birth: The Maternal-Fetal Medicine Division has published on the use of cDNA microarray to identify genes with labor-specific expression within myometrium and has also reported on cytokine polymorphisms and spontaneous preterm birth in various ethnic populations. We have also recently reported experience with the use of proteomics to identify potential predictors of term and preterm birth. IV. Reproductive and Medical Genetics: Utah's distinct population has attracted numerous world-class geneticists to the University. State of the art molecular and clinical genetic capabilities will be made available to the Network. V. University / Community Synergy: MFM specialists in Utah have a unique clinical and research partnership that crosses competing health care systems and affords universal access to patients for clinical research. VI. Proven Enrollment Strategy: Research infrastructure is currently in place at four regional tertiary care centers that has and will continue to allow the University of Utah to be among the leading recruitment centers for large multicenter trials.

描述（由申请人提供）：本提案构成了犹他州大学对NICHD早产研究基因组和蛋白质组网络的申请。犹他州大学拥有众多独特的优势，使其成为网络的理想中心。这些措施包括：多中心合作研究的研究生产力：犹他州大学母胎医学（MFM）部门在过去五年中为超过15项多中心临床试验做出了重大贡献，并且是NICHD/MFMU网络的领先招募中心。超过12,000名犹他州患者参加了最近完成的FASTER试验，占12个中心试验受试者的近32%。犹他州大学还参加了死产合作研究网络和全球妇女和儿童健康研究网络。二.早产：犹他州大学享有国际公认的早产临床护理和研究的卓越中心。三.利用基因组学和蛋白质组学技术研究早产的专业知识：母胎医学部发表了关于利用cDNA微阵列鉴定子宫肌层内具有劳动力特异性表达的基因的文章，还报道了不同种族人群中细胞因子多态性和自发性早产的情况。我们最近还报道了使用蛋白质组学来确定足月和早产的潜在预测因子的经验。四.生殖和医学遗传学：犹他州独特的人口吸引了许多世界级的遗传学家到大学。将向该网络提供最先进的分子和临床遗传能力。五、大学/社区协同作用：犹他州的MFM专家拥有独特的临床和研究伙伴关系，该伙伴关系跨越了相互竞争的医疗保健系统，并为患者提供了普遍的临床研究机会。六.招生策略：研究基础设施目前在四个地区三级保健中心已经到位，并将继续允许犹他州大学成为大型多中心试验的领先招募中心。